Inhibition of quorum sensing in Vibrio harveyi by boronic acids

Nanting Ni, Gaurav Choudhary, Hanjing Peng, Minyong Li, Han Ting Chou, Chung Dar Lu, Eric S. Gilbert, Binghe Wang

Research output: Contribution to journalArticle

Abstract

Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chemicals called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. In this paper, we describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC50 values in the low to sub-micromolar range in whole cell assays.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalChemical Biology and Drug Design
Volume74
Issue number1
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

Keywords

  • Autoinducer-1
  • Autoinducer-2
  • Inhibitors
  • Luminescence

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Ni, N., Choudhary, G., Peng, H., Li, M., Chou, H. T., Lu, C. D., Gilbert, E. S., & Wang, B. (2009). Inhibition of quorum sensing in Vibrio harveyi by boronic acids. Chemical Biology and Drug Design, 74(1), 51-56. https://doi.org/10.1111/j.1747-0285.2009.00834.x