Inhibition of platelet energy production and release reaction by PGE1, theophylline and cAMP

Sidney M. Wolfe, N. Raphael Shulman

Research output: Contribution to journalArticlepeer-review


Thrombin induces a rapid, simultaneous release from platelets of adenine nucleotides and calcium in a constant molar ratio. PGE1, theophylline, and dibutyryl cyclic AMP inhibit this release reaction, the attendant lactate production, and the subsequent aggregation of platelets. Compounds which result in increased intracellular levels of cAMP appear to block aggregation by inhibiting the release reaction and energy production.

Original languageEnglish (US)
Pages (from-to)128-134
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Oct 9 1970

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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