Inhibition of platelet energy production and release reaction by PGE1, theophylline and cAMP

Sidney M. Wolfe, N. Raphael Shulman

Research output: Contribution to journalArticle

Abstract

Thrombin induces a rapid, simultaneous release from platelets of adenine nucleotides and calcium in a constant molar ratio. PGE1, theophylline, and dibutyryl cyclic AMP inhibit this release reaction, the attendant lactate production, and the subsequent aggregation of platelets. Compounds which result in increased intracellular levels of cAMP appear to block aggregation by inhibiting the release reaction and energy production.

Original languageEnglish (US)
Pages (from-to)128-134
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume41
Issue number1
DOIs
StatePublished - Oct 9 1970

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Inhibition of platelet energy production and release reaction by PGE<sub>1</sub>, theophylline and cAMP'. Together they form a unique fingerprint.

  • Cite this