Inhibition of mitogenesis in bovine lymphocytes by juvenile hormones

Thomas W. Kensler, Gerald C. Mueller

Research output: Contribution to journalArticle

Abstract

Phytohemagglutinin and the co-carcinogenic phorbol ester, 12-0- tetradecanoyl-phorbol-13-acetate, act synergistically in cultures of bovine lymphocytes to induce a mitogenic response. Insect juvinile hormones appear to act selectively to block or counteract an early hormones appear to act selectively to block or counteract an early event in the induction of DNA and nuclear replication while allowing other blastogenic events such as increases in RNA and protein synthesis and cell size to occur.

Original languageEnglish (US)
Pages (from-to)505-509
Number of pages5
JournalLife Sciences
Volume22
Issue number6
DOIs
StatePublished - Feb 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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