Inhibition of mitogenesis in bovine lymphocytes by juvenile hormones

Thomas W. Kensler; Gerald C. Mueller

doi:10.1016/0024-3205(78)90431-9

Inhibition of mitogenesis in bovine lymphocytes by juvenile hormones

Thomas W. Kensler, Gerald C. Mueller

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Phytohemagglutinin and the co-carcinogenic phorbol ester, 12-0- tetradecanoyl-phorbol-13-acetate, act synergistically in cultures of bovine lymphocytes to induce a mitogenic response. Insect juvinile hormones appear to act selectively to block or counteract an early hormones appear to act selectively to block or counteract an early event in the induction of DNA and nuclear replication while allowing other blastogenic events such as increases in RNA and protein synthesis and cell size to occur.

Original language	English (US)
Pages (from-to)	505-509
Number of pages	5
Journal	Life Sciences
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/0024-3205(78)90431-9
State	Published - Feb 1978
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(78)90431-9

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title = "Inhibition of mitogenesis in bovine lymphocytes by juvenile hormones",

abstract = "Phytohemagglutinin and the co-carcinogenic phorbol ester, 12-0- tetradecanoyl-phorbol-13-acetate, act synergistically in cultures of bovine lymphocytes to induce a mitogenic response. Insect juvinile hormones appear to act selectively to block or counteract an early hormones appear to act selectively to block or counteract an early event in the induction of DNA and nuclear replication while allowing other blastogenic events such as increases in RNA and protein synthesis and cell size to occur.",

author = "Kensler, {Thomas W.} and Mueller, {Gerald C.}",

note = "Funding Information: We thank Ms . Mary LeMahieu for her help in the preparation of this manuscript . This study was supported by U .S . Public Health Service Grants TOI-CA-5002, CA-07175 and NIH Training Grant T32-CA-09020 . GCM is the recipient of a Research Career Award, U .S . Public Health Service .",

year = "1978",

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doi = "10.1016/0024-3205(78)90431-9",

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T1 - Inhibition of mitogenesis in bovine lymphocytes by juvenile hormones

AU - Kensler, Thomas W.

AU - Mueller, Gerald C.

N1 - Funding Information: We thank Ms . Mary LeMahieu for her help in the preparation of this manuscript . This study was supported by U .S . Public Health Service Grants TOI-CA-5002, CA-07175 and NIH Training Grant T32-CA-09020 . GCM is the recipient of a Research Career Award, U .S . Public Health Service .

PY - 1978/2

Y1 - 1978/2

N2 - Phytohemagglutinin and the co-carcinogenic phorbol ester, 12-0- tetradecanoyl-phorbol-13-acetate, act synergistically in cultures of bovine lymphocytes to induce a mitogenic response. Insect juvinile hormones appear to act selectively to block or counteract an early hormones appear to act selectively to block or counteract an early event in the induction of DNA and nuclear replication while allowing other blastogenic events such as increases in RNA and protein synthesis and cell size to occur.

AB - Phytohemagglutinin and the co-carcinogenic phorbol ester, 12-0- tetradecanoyl-phorbol-13-acetate, act synergistically in cultures of bovine lymphocytes to induce a mitogenic response. Insect juvinile hormones appear to act selectively to block or counteract an early hormones appear to act selectively to block or counteract an early event in the induction of DNA and nuclear replication while allowing other blastogenic events such as increases in RNA and protein synthesis and cell size to occur.

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JO - Life Sciences

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ER -

Inhibition of mitogenesis in bovine lymphocytes by juvenile hormones

Abstract

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