Inhibition of lipoxygenase-mediated lipid peroxidation by eugenol in a liposomal system

Enika Nagababu, Nakka Lakshmaiah

Research output: Contribution to journalArticle

Abstract

The effect of eugenol on lipoxygenase-catalyzed lipid peroxidation was studied in aqueous solution and in microsomal lipid liposomes. Eugenol did not inhibit lipoxygenase-catalyzed linoleic acid hydroperoxide formation in aqueous medium as assessed by oxygen uptake and linoleic acid hydroperoxide formation. However, using the same criteria and formation of thiobarbituric acid-reactive substances, we found that eugenol inhibited lipid oxygenation when the reaction was carried out in linoleic acid-containing liposomes. These results suggest that the peroxyl and carbon-centered radical intermediates generated by lipoxygenase in a membrane environment are readily accessible to eugenol for quenching and concomitant inhibition of lipid peroxidation.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalJournal of Clinical Biochemistry and Nutrition
Volume21
Issue number2
DOIs
StatePublished - Sep 1996

Keywords

  • eugenol
  • lipid peroxidation
  • lipoxygenase
  • microsomal lipid liposomes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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