Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials

R. S. Wallis, M. Phillips, J. L. Johnson, L. Teixeira, L. M M C Rocha, E. Maciel, L. Rose, C. Wells, M. Palaci, R. Dietze, K. Eisenach, J. J. Ellner

Research output: Contribution to journalArticlepeer-review

Abstract

Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.

Original languageEnglish (US)
Pages (from-to)1302-1304
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials'. Together they form a unique fingerprint.

Cite this