Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials

R. S. Wallis; M. Phillips; J. L. Johnson; L. Teixeira; L. M M C Rocha; E. Maciel; L. Rose; C. Wells; M. Palaci; R. Dietze; K. Eisenach; J. J. Ellner

doi:10.1128/AAC.45.4.1302-1304.2001

Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials

R. S. Wallis, M. Phillips, J. L. Johnson, L. Teixeira, L. M M C Rocha, E. Maciel, L. Rose, C. Wells, M. Palaci, R. Dietze, K. Eisenach, J. J. Ellner

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.

Original language	English (US)
Pages (from-to)	1302-1304
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	45
Issue number	4
DOIs	https://doi.org/10.1128/AAC.45.4.1302-1304.2001
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)

Access to Document

10.1128/AAC.45.4.1302-1304.2001

Cite this

Wallis, R. S., Phillips, M., Johnson, J. L., Teixeira, L., Rocha, L. M. M. C., Maciel, E., Rose, L., Wells, C., Palaci, M., Dietze, R., Eisenach, K., & Ellner, J. J. (2001). Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials. Antimicrobial Agents and Chemotherapy, 45(4), 1302-1304. https://doi.org/10.1128/AAC.45.4.1302-1304.2001

Wallis, RS, Phillips, M, Johnson, JL, Teixeira, L, Rocha, LMMC, Maciel, E, Rose, L, Wells, C, Palaci, M, Dietze, R, Eisenach, K & Ellner, JJ 2001, 'Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials', Antimicrobial Agents and Chemotherapy, vol. 45, no. 4, pp. 1302-1304. https://doi.org/10.1128/AAC.45.4.1302-1304.2001

@article{42437a2afd3642c9a0417ad07262b364,

title = "Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials",

abstract = "Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.",

author = "Wallis, {R. S.} and M. Phillips and Johnson, {J. L.} and L. Teixeira and Rocha, {L. M M C} and E. Maciel and L. Rose and C. Wells and M. Palaci and R. Dietze and K. Eisenach and Ellner, {J. J.}",

year = "2001",

doi = "10.1128/AAC.45.4.1302-1304.2001",

language = "English (US)",

volume = "45",

pages = "1302--1304",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "4",

}

TY - JOUR

T1 - Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum

T2 - Potential surrogate marker in tuberculosis chemotherapy trials

AU - Wallis, R. S.

AU - Phillips, M.

AU - Johnson, J. L.

AU - Teixeira, L.

AU - Rocha, L. M M C

AU - Maciel, E.

AU - Rose, L.

AU - Wells, C.

AU - Palaci, M.

AU - Dietze, R.

AU - Eisenach, K.

AU - Ellner, J. J.

PY - 2001

Y1 - 2001

N2 - Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.

AB - Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.

UR - http://www.scopus.com/inward/record.url?scp=0035080889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035080889&partnerID=8YFLogxK

U2 - 10.1128/AAC.45.4.1302-1304.2001

DO - 10.1128/AAC.45.4.1302-1304.2001

M3 - Article

C2 - 11257053

AN - SCOPUS:0035080889

SN - 0066-4804

VL - 45

SP - 1302

EP - 1304

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

ER -

Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this