Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials

R. S. Wallis, M. Phillips, J. L. Johnson, L. Teixeira, L. M M C Rocha, E. Maciel, L. Rose, C. Wells, M. Palaci, R. Dietze, K. Eisenach, J. J. Ellner

Research output: Contribution to journalArticle

Abstract

Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.

Original languageEnglish (US)
Pages (from-to)1302-1304
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

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KRM 1648
Isoniazid
Sputum
Tuberculosis
Biomarkers
Drug Therapy
Rifampin
Antigens
Recurrence
Pharmaceutical Preparations
Mycobacterium tuberculosis antigens
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum : Potential surrogate marker in tuberculosis chemotherapy trials. / Wallis, R. S.; Phillips, M.; Johnson, J. L.; Teixeira, L.; Rocha, L. M M C; Maciel, E.; Rose, L.; Wells, C.; Palaci, M.; Dietze, R.; Eisenach, K.; Ellner, J. J.

In: Antimicrobial Agents and Chemotherapy, Vol. 45, No. 4, 2001, p. 1302-1304.

Research output: Contribution to journalArticle

Wallis, RS, Phillips, M, Johnson, JL, Teixeira, L, Rocha, LMMC, Maciel, E, Rose, L, Wells, C, Palaci, M, Dietze, R, Eisenach, K & Ellner, JJ 2001, 'Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: Potential surrogate marker in tuberculosis chemotherapy trials', Antimicrobial Agents and Chemotherapy, vol. 45, no. 4, pp. 1302-1304. https://doi.org/10.1128/AAC.45.4.1302-1304.2001
Wallis, R. S. ; Phillips, M. ; Johnson, J. L. ; Teixeira, L. ; Rocha, L. M M C ; Maciel, E. ; Rose, L. ; Wells, C. ; Palaci, M. ; Dietze, R. ; Eisenach, K. ; Ellner, J. J. / Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum : Potential surrogate marker in tuberculosis chemotherapy trials. In: Antimicrobial Agents and Chemotherapy. 2001 ; Vol. 45, No. 4. pp. 1302-1304.
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