Inhibition of idiotype - Anti-idiotype interaction for detection of a parasite antigen

A new immunoassay

Pedro Potocnjak, Fidel P Zavala, Ruth Nussenzweig, Victor Nussenzweig

Research output: Contribution to journalArticle

Abstract

Described in this report is an immunoradiometric assay of general applicability that is based on a new principle: the inhibition of the interaction between monoclonal antibodies by an antigen. The advantages of this assay are that it measures concentrations of single epitopes, purified antigen is not required, and the reagents can be obtained in unlimited amounts and are homogeneous. Its features are particularly attractive when the antigen has not been purified and is a minor component of a complex mixture of molecules.

Original languageEnglish (US)
Pages (from-to)1637-1639
Number of pages3
JournalScience
Volume216
Issue number4540
StatePublished - 1982
Externally publishedYes

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Immunoassay
Parasites
Antigens
Immunoradiometric Assay
Complex Mixtures
Epitopes
Monoclonal Antibodies

ASJC Scopus subject areas

  • General

Cite this

Inhibition of idiotype - Anti-idiotype interaction for detection of a parasite antigen : A new immunoassay. / Potocnjak, Pedro; Zavala, Fidel P; Nussenzweig, Ruth; Nussenzweig, Victor.

In: Science, Vol. 216, No. 4540, 1982, p. 1637-1639.

Research output: Contribution to journalArticle

Potocnjak, P, Zavala, FP, Nussenzweig, R & Nussenzweig, V 1982, 'Inhibition of idiotype - Anti-idiotype interaction for detection of a parasite antigen: A new immunoassay', Science, vol. 216, no. 4540, pp. 1637-1639.
Potocnjak, Pedro ; Zavala, Fidel P ; Nussenzweig, Ruth ; Nussenzweig, Victor. / Inhibition of idiotype - Anti-idiotype interaction for detection of a parasite antigen : A new immunoassay. In: Science. 1982 ; Vol. 216, No. 4540. pp. 1637-1639.
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