Inhibition of glucose-stimulated insulin release in the perfused rat pancreas by parathyroid secretory protein-I (chromogranin-A)

G. H. Greeley, J. C. Thompson, J. Ishizuka, C. W. Cooper, M. A. Levine, S. U. Gorr, D. V. Cohn

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    Abstract

    The effect of graded doses (10-10-10-8 M) of highly purified bovine parathyroid secretory protein-I (SP-I; chromogranin-A) or synthetic porcine pancreastatin on glucose-stimulated insulin release in the perfused rat pancreas was examined. SP-I (10-9 M) inhibited the first phase of glucose-stimulated insulin release, and 10-8 M SP-I inhibited both the first and second phases of glucose-stimulated insulin release; 10-10 M SP-I was inactive. In comparison, pancreastatin at 10-10 M inhibited the first phase of insulin release, and at 10-9 and 10-8 M, pancreastatin inhibited both phases of insulin release. The inhibition by SP-I was achieved at concentrations that normally exist in the general circulation of man. These and other data suggest that circulating SP-I plays a physiological role in the regulation of insulin secretion.

    Original languageEnglish (US)
    Pages (from-to)1235-1238
    Number of pages4
    JournalEndocrinology
    Volume124
    Issue number3
    Publication statusPublished - 1989

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    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Greeley, G. H., Thompson, J. C., Ishizuka, J., Cooper, C. W., Levine, M. A., Gorr, S. U., & Cohn, D. V. (1989). Inhibition of glucose-stimulated insulin release in the perfused rat pancreas by parathyroid secretory protein-I (chromogranin-A). Endocrinology, 124(3), 1235-1238.