Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro

Albert Leyva; Hillie Appel; Peter Smith; Jan Lankelma; Herbert M. Pinedo

doi:10.1016/0304-3835(81)90053-7

Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro

Albert Leyva, Hillie Appel, Peter Smith, Jan Lankelma, Herbert M. Pinedo

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Two murine cell lines, L1210 leukemia (T-cell) and B16 melanoma, and 3 human cell lines, CCRF-CEM leukemia (T-cell), NC37 lymphoblasts (B-cell) and IPC-48 melanoma were compared with respect to sensitivity to N-(phosphonacetyl)-L-aspartate (PALA), growth rate and aspartate transcarbamylase activity. No correlation between drug sensitivity and growth rate was found. The melanoma cell lines were more sensitive to PALA than were the lymphocytic cell lines. The 2 T-cell leukemia lines had similar sensitivities to PALA while the B-lymphoblasts were more resistant at 10^-3 M PALA and less resistant at 10^-4 M PALA than were L1210 and CCRF-CEM cells. Aspartate transcarbamylase activity was similar among the 2 melanoma cell lines and among the 3 lymphocytic cell lines and was 2-fold higher in the latter.

Original language	English (US)
Pages (from-to)	169-173
Number of pages	5
Journal	Cancer Letters
Volume	12
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3835(81)90053-7
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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title = "Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro",

abstract = "Two murine cell lines, L1210 leukemia (T-cell) and B16 melanoma, and 3 human cell lines, CCRF-CEM leukemia (T-cell), NC37 lymphoblasts (B-cell) and IPC-48 melanoma were compared with respect to sensitivity to N-(phosphonacetyl)-L-aspartate (PALA), growth rate and aspartate transcarbamylase activity. No correlation between drug sensitivity and growth rate was found. The melanoma cell lines were more sensitive to PALA than were the lymphocytic cell lines. The 2 T-cell leukemia lines had similar sensitivities to PALA while the B-lymphoblasts were more resistant at 10-3 M PALA and less resistant at 10-4 M PALA than were L1210 and CCRF-CEM cells. Aspartate transcarbamylase activity was similar among the 2 melanoma cell lines and among the 3 lymphocytic cell lines and was 2-fold higher in the latter.",

author = "Albert Leyva and Hillie Appel and Peter Smith and Jan Lankelma and Pinedo, {Herbert M.}",

year = "1981",

doi = "10.1016/0304-3835(81)90053-7",

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T1 - Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro

AU - Leyva, Albert

AU - Appel, Hillie

AU - Smith, Peter

AU - Lankelma, Jan

AU - Pinedo, Herbert M.

PY - 1981

Y1 - 1981

N2 - Two murine cell lines, L1210 leukemia (T-cell) and B16 melanoma, and 3 human cell lines, CCRF-CEM leukemia (T-cell), NC37 lymphoblasts (B-cell) and IPC-48 melanoma were compared with respect to sensitivity to N-(phosphonacetyl)-L-aspartate (PALA), growth rate and aspartate transcarbamylase activity. No correlation between drug sensitivity and growth rate was found. The melanoma cell lines were more sensitive to PALA than were the lymphocytic cell lines. The 2 T-cell leukemia lines had similar sensitivities to PALA while the B-lymphoblasts were more resistant at 10-3 M PALA and less resistant at 10-4 M PALA than were L1210 and CCRF-CEM cells. Aspartate transcarbamylase activity was similar among the 2 melanoma cell lines and among the 3 lymphocytic cell lines and was 2-fold higher in the latter.

AB - Two murine cell lines, L1210 leukemia (T-cell) and B16 melanoma, and 3 human cell lines, CCRF-CEM leukemia (T-cell), NC37 lymphoblasts (B-cell) and IPC-48 melanoma were compared with respect to sensitivity to N-(phosphonacetyl)-L-aspartate (PALA), growth rate and aspartate transcarbamylase activity. No correlation between drug sensitivity and growth rate was found. The melanoma cell lines were more sensitive to PALA than were the lymphocytic cell lines. The 2 T-cell leukemia lines had similar sensitivities to PALA while the B-lymphoblasts were more resistant at 10-3 M PALA and less resistant at 10-4 M PALA than were L1210 and CCRF-CEM cells. Aspartate transcarbamylase activity was similar among the 2 melanoma cell lines and among the 3 lymphocytic cell lines and was 2-fold higher in the latter.

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JO - Cancer Letters

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ER -

Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro

Abstract

ASJC Scopus subject areas

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