Inhibition of cell growth by N-(phosphonacetyl)-L-aspartate in human and murine cells in vitro

Albert Leyva, Hillie Appel, Peter Smith, Jan Lankelma, Herbert M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

Two murine cell lines, L1210 leukemia (T-cell) and B16 melanoma, and 3 human cell lines, CCRF-CEM leukemia (T-cell), NC37 lymphoblasts (B-cell) and IPC-48 melanoma were compared with respect to sensitivity to N-(phosphonacetyl)-L-aspartate (PALA), growth rate and aspartate transcarbamylase activity. No correlation between drug sensitivity and growth rate was found. The melanoma cell lines were more sensitive to PALA than were the lymphocytic cell lines. The 2 T-cell leukemia lines had similar sensitivities to PALA while the B-lymphoblasts were more resistant at 10-3 M PALA and less resistant at 10-4 M PALA than were L1210 and CCRF-CEM cells. Aspartate transcarbamylase activity was similar among the 2 melanoma cell lines and among the 3 lymphocytic cell lines and was 2-fold higher in the latter.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalCancer Letters
Volume12
Issue number1-2
DOIs
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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