Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones

Medicine & Life Sciences

• cdc25 Phosphatases 100%
• Catalytic Domain 55%
• Lead 28%
• quinone 24%
• 2,5-dihydroxy-1,4-benzoquinone 24%
• Structure-Activity Relationship 12%
• Sulfhydryl Compounds 11%
• Anions 11%
• Drug Discovery 10%
• Cell Cycle Checkpoints 9%
• Carrier Proteins 8%
• Cell Death 7%
• Mutation 5%
• In Vitro Techniques 4%
• Pharmaceutical Preparations 4%
• Proteins 3%
• Neoplasms 3%
• Therapeutics 1%

Chemical Compounds

• 1,4-benzoquinone 82%
• Thiolate Anion 30%
• Cell Death 21%
• Molecule 21%
• Structure-Activity Relationship 17%
• Mutation 17%
• Thiol 17%
• Protein 16%
• Adduct 14%
• Modification 11%
• Drug 10%
• Reaction Yield 8%