Inhibition of apoptosis during development of colorectal cancer

Atul Bedi, P. J. Pasricha, A. J. Akhtar, J. P. Barber, Richard J Jones, Pankaj Jay Pasricha, Francis M Giardiello, S. R. Hamilton, R. J. Jones

Research output: Contribution to journalArticle

Abstract

Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations. Studies of the mechanism by which these genetic changes effect malignant transformation have focused on the deregulation of cell proliferation. However, colorectal epithelial homeostasis is dependent not only on the rate of cell production but also on apoptosis, a genetically programmed process of autonomous cell death. We investigated whether colorectal tumorigenesis involved an altered susceptibility to apoptosis by examining colorectal epithelium from normal mucosa, adenomas from familial adenomatous polyposis, sporadic adenomas, and carcinomas. The transformation of colorectal epithelium to carcinomas was associated with a progressive inhibition of apoptosis. The inhibition of apoptosis in colorectal cancers may contribute to tumor growth, promote neoplastic progression, and confer resistance to cytotoxic anticancer agents.

Original languageEnglish (US)
Pages (from-to)1811-1816
Number of pages6
JournalCancer Research
Volume55
Issue number9
StatePublished - 1995

Fingerprint

Colorectal Neoplasms
Apoptosis
Adenoma
Carcinogenesis
Epithelium
Carcinoma
Adenomatous Polyposis Coli
Cytotoxins
Antineoplastic Agents
Mucous Membrane
Homeostasis
Cell Death
Cell Proliferation
Growth
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bedi, A., Pasricha, P. J., Akhtar, A. J., Barber, J. P., Jones, R. J., Pasricha, P. J., ... Jones, R. J. (1995). Inhibition of apoptosis during development of colorectal cancer. Cancer Research, 55(9), 1811-1816.

Inhibition of apoptosis during development of colorectal cancer. / Bedi, Atul; Pasricha, P. J.; Akhtar, A. J.; Barber, J. P.; Jones, Richard J; Pasricha, Pankaj Jay; Giardiello, Francis M; Hamilton, S. R.; Jones, R. J.

In: Cancer Research, Vol. 55, No. 9, 1995, p. 1811-1816.

Research output: Contribution to journalArticle

Bedi, A, Pasricha, PJ, Akhtar, AJ, Barber, JP, Jones, RJ, Pasricha, PJ, Giardiello, FM, Hamilton, SR & Jones, RJ 1995, 'Inhibition of apoptosis during development of colorectal cancer', Cancer Research, vol. 55, no. 9, pp. 1811-1816.
Bedi, Atul ; Pasricha, P. J. ; Akhtar, A. J. ; Barber, J. P. ; Jones, Richard J ; Pasricha, Pankaj Jay ; Giardiello, Francis M ; Hamilton, S. R. ; Jones, R. J. / Inhibition of apoptosis during development of colorectal cancer. In: Cancer Research. 1995 ; Vol. 55, No. 9. pp. 1811-1816.
@article{a622669c1e4243a3a8b9e1643c6ffa5c,
title = "Inhibition of apoptosis during development of colorectal cancer",
abstract = "Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations. Studies of the mechanism by which these genetic changes effect malignant transformation have focused on the deregulation of cell proliferation. However, colorectal epithelial homeostasis is dependent not only on the rate of cell production but also on apoptosis, a genetically programmed process of autonomous cell death. We investigated whether colorectal tumorigenesis involved an altered susceptibility to apoptosis by examining colorectal epithelium from normal mucosa, adenomas from familial adenomatous polyposis, sporadic adenomas, and carcinomas. The transformation of colorectal epithelium to carcinomas was associated with a progressive inhibition of apoptosis. The inhibition of apoptosis in colorectal cancers may contribute to tumor growth, promote neoplastic progression, and confer resistance to cytotoxic anticancer agents.",
author = "Atul Bedi and Pasricha, {P. J.} and Akhtar, {A. J.} and Barber, {J. P.} and Jones, {Richard J} and Pasricha, {Pankaj Jay} and Giardiello, {Francis M} and Hamilton, {S. R.} and Jones, {R. J.}",
year = "1995",
language = "English (US)",
volume = "55",
pages = "1811--1816",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "9",

}

TY - JOUR

T1 - Inhibition of apoptosis during development of colorectal cancer

AU - Bedi, Atul

AU - Pasricha, P. J.

AU - Akhtar, A. J.

AU - Barber, J. P.

AU - Jones, Richard J

AU - Pasricha, Pankaj Jay

AU - Giardiello, Francis M

AU - Hamilton, S. R.

AU - Jones, R. J.

PY - 1995

Y1 - 1995

N2 - Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations. Studies of the mechanism by which these genetic changes effect malignant transformation have focused on the deregulation of cell proliferation. However, colorectal epithelial homeostasis is dependent not only on the rate of cell production but also on apoptosis, a genetically programmed process of autonomous cell death. We investigated whether colorectal tumorigenesis involved an altered susceptibility to apoptosis by examining colorectal epithelium from normal mucosa, adenomas from familial adenomatous polyposis, sporadic adenomas, and carcinomas. The transformation of colorectal epithelium to carcinomas was associated with a progressive inhibition of apoptosis. The inhibition of apoptosis in colorectal cancers may contribute to tumor growth, promote neoplastic progression, and confer resistance to cytotoxic anticancer agents.

AB - Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations. Studies of the mechanism by which these genetic changes effect malignant transformation have focused on the deregulation of cell proliferation. However, colorectal epithelial homeostasis is dependent not only on the rate of cell production but also on apoptosis, a genetically programmed process of autonomous cell death. We investigated whether colorectal tumorigenesis involved an altered susceptibility to apoptosis by examining colorectal epithelium from normal mucosa, adenomas from familial adenomatous polyposis, sporadic adenomas, and carcinomas. The transformation of colorectal epithelium to carcinomas was associated with a progressive inhibition of apoptosis. The inhibition of apoptosis in colorectal cancers may contribute to tumor growth, promote neoplastic progression, and confer resistance to cytotoxic anticancer agents.

UR - http://www.scopus.com/inward/record.url?scp=0028941441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028941441&partnerID=8YFLogxK

M3 - Article

C2 - 7728743

AN - SCOPUS:0028941441

VL - 55

SP - 1811

EP - 1816

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 9

ER -