Inhibition of angiogenesis in cancer patients

Henk M W Verheul, Herbert M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment with antiangiogenic agents as standard anticancer therapy with or without classical chemotherapy is rapidly approaching. The clinical efficacy of bevacizumab in colorectal cancer in combination with chemotherapy caused a revival of the antiangiogenic strategy. By combining this agent with a tyrosine kinase receptor epidermal growth factor receptor blocker (erlotinib), remarkable responses were seen in renal cell cancer. It has been thought that blocking these biological pathways would cause no drug-related toxicity, but a whole new pattern of relatively mild side effects compared with classical chemotherapy, including skin rash, fatigue and hypertension, has been observed. In combination with chemotherapy, other serious side effects, such as bleeding and thrombosis, also occur. Here, the preclinical and clinical data of antiangiogenic agents in clinical trials at this moment are summarised.

Original languageEnglish (US)
Pages (from-to)403-412
Number of pages10
JournalExpert Opinion on Emerging Drugs
Volume10
Issue number2
DOIs
StatePublished - May 2005
Externally publishedYes

Keywords

  • Angiogenesis
  • Antiangiogenic
  • Cancer
  • Tyrosine kinase receptors
  • VEGF

ASJC Scopus subject areas

  • Pharmacology

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