Vasoactive intestinal peptide (VIP) was found to inhibit ovalbumin-induced histamine release from guinea-pig minced lung. Maximum inhibition occured with a 10-20 min time of preincubation with VIP. Spontaneous histamine release was not altered by VIP. With 2 × 10-6 M VIP, the dose-response curve to ovalbumin was shifted about 3-fold to the right, but the maximum histamine release was unaltered. Respiratory tract infection with parainfluenza 3 virus did not influence the inhibitory effect of VIP on histamine release.
- Guinea-pig lung
- Histamine release
- Parainfluenza 3 injection
- Vasoactive intestinal peptide
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