Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung

Bradley J. Undem; Elliot C. Dick; Carl K. Buckner

doi:10.1016/0014-2999(83)90012-2

Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung

Bradley J. Undem, Elliot C. Dick, Carl K. Buckner

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Vasoactive intestinal peptide (VIP) was found to inhibit ovalbumin-induced histamine release from guinea-pig minced lung. Maximum inhibition occured with a 10-20 min time of preincubation with VIP. Spontaneous histamine release was not altered by VIP. With 2 × 10^-6 M VIP, the dose-response curve to ovalbumin was shifted about 3-fold to the right, but the maximum histamine release was unaltered. Respiratory tract infection with parainfluenza 3 virus did not influence the inhibitory effect of VIP on histamine release.

Original language	English (US)
Pages (from-to)	247-250
Number of pages	4
Journal	European Journal of Pharmacology
Volume	88
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(83)90012-2
State	Published - Mar 25 1983
Externally published	Yes

Keywords

Guinea-pig lung
Histamine release
Parainfluenza 3 injection
Vasoactive intestinal peptide

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(83)90012-2

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title = "Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung",

abstract = "Vasoactive intestinal peptide (VIP) was found to inhibit ovalbumin-induced histamine release from guinea-pig minced lung. Maximum inhibition occured with a 10-20 min time of preincubation with VIP. Spontaneous histamine release was not altered by VIP. With 2 × 10-6 M VIP, the dose-response curve to ovalbumin was shifted about 3-fold to the right, but the maximum histamine release was unaltered. Respiratory tract infection with parainfluenza 3 virus did not influence the inhibitory effect of VIP on histamine release.",

keywords = "Guinea-pig lung, Histamine release, Parainfluenza 3 injection, Vasoactive intestinal peptide",

author = "Undem, {Bradley J.} and Dick, {Elliot C.} and Buckner, {Carl K.}",

note = "Funding Information: * This work was supported by U.S. Public Health Service Grant AI-10404. ** To whom all correspondence should be addressed: School of Pharmacy, University of Wisconsin, 425 North Charter Street, Madison, Wisonsin 53706, U.S.A.",

year = "1983",

month = mar,

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doi = "10.1016/0014-2999(83)90012-2",

language = "English (US)",

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pages = "247--250",

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T1 - Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung

AU - Undem, Bradley J.

AU - Dick, Elliot C.

AU - Buckner, Carl K.

N1 - Funding Information: * This work was supported by U.S. Public Health Service Grant AI-10404. ** To whom all correspondence should be addressed: School of Pharmacy, University of Wisconsin, 425 North Charter Street, Madison, Wisonsin 53706, U.S.A.

PY - 1983/3/25

Y1 - 1983/3/25

N2 - Vasoactive intestinal peptide (VIP) was found to inhibit ovalbumin-induced histamine release from guinea-pig minced lung. Maximum inhibition occured with a 10-20 min time of preincubation with VIP. Spontaneous histamine release was not altered by VIP. With 2 × 10-6 M VIP, the dose-response curve to ovalbumin was shifted about 3-fold to the right, but the maximum histamine release was unaltered. Respiratory tract infection with parainfluenza 3 virus did not influence the inhibitory effect of VIP on histamine release.

AB - Vasoactive intestinal peptide (VIP) was found to inhibit ovalbumin-induced histamine release from guinea-pig minced lung. Maximum inhibition occured with a 10-20 min time of preincubation with VIP. Spontaneous histamine release was not altered by VIP. With 2 × 10-6 M VIP, the dose-response curve to ovalbumin was shifted about 3-fold to the right, but the maximum histamine release was unaltered. Respiratory tract infection with parainfluenza 3 virus did not influence the inhibitory effect of VIP on histamine release.

KW - Guinea-pig lung

KW - Histamine release

KW - Parainfluenza 3 injection

KW - Vasoactive intestinal peptide

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JF - European Journal of Pharmacology

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ER -

Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung

Abstract

Keywords

ASJC Scopus subject areas

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