Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung

Bradley J. Undem, Elliot C. Dick, Carl K. Buckner

Research output: Contribution to journalArticlepeer-review

Abstract

Vasoactive intestinal peptide (VIP) was found to inhibit ovalbumin-induced histamine release from guinea-pig minced lung. Maximum inhibition occured with a 10-20 min time of preincubation with VIP. Spontaneous histamine release was not altered by VIP. With 2 × 10-6 M VIP, the dose-response curve to ovalbumin was shifted about 3-fold to the right, but the maximum histamine release was unaltered. Respiratory tract infection with parainfluenza 3 virus did not influence the inhibitory effect of VIP on histamine release.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalEuropean Journal of Pharmacology
Volume88
Issue number2-3
DOIs
StatePublished - Mar 25 1983
Externally publishedYes

Keywords

  • Guinea-pig lung
  • Histamine release
  • Parainfluenza 3 injection
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Pharmacology

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