TY - JOUR
T1 - Inherited pancreatic cancer
AU - Chen, Fei
AU - Roberts, Nicholas J.
AU - Klein, Alison P.
N1 - Funding Information:
This work is supported the NIH Specialized Programs of Research Excellence P50-CA062924, NIH grants R00-CA190889 and R01-CA154823 and the Lustgarten Foundation for Pancreatic Cancer Research and the Sol Goldman Pancreatic Cancer Research Center and the Burroughs-Wellcome Fund Maryland: Genetics, Epidemiology and Medicine Training Grant
Publisher Copyright:
© Chinese Clinical Oncology.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Pancreatic cancers arise through a series of genetic events both inherited and acquired. Inherited genetic changes, both high penetrance and low penetrance, are an important component of pancreatic cancer risk, and may be used to characterize populations who will benefit from early detection. Furthermore, pancreatic cancer patients with inherited mutations may be particularly sensitive to certain targeted agents, providing an opportunity to personalized treatment. Family history of pancreatic cancer is one of the strongest risk factors for the disease, and is associated with an increased risk of caners at other sites, including but not limited to breast, ovarian and colorectal cancer. The goal of this chapter is to discuss the importance of family history of pancreatic cancer, and the known genes that account for a portion of the familial clustering of pancreatic cancer.
AB - Pancreatic cancers arise through a series of genetic events both inherited and acquired. Inherited genetic changes, both high penetrance and low penetrance, are an important component of pancreatic cancer risk, and may be used to characterize populations who will benefit from early detection. Furthermore, pancreatic cancer patients with inherited mutations may be particularly sensitive to certain targeted agents, providing an opportunity to personalized treatment. Family history of pancreatic cancer is one of the strongest risk factors for the disease, and is associated with an increased risk of caners at other sites, including but not limited to breast, ovarian and colorectal cancer. The goal of this chapter is to discuss the importance of family history of pancreatic cancer, and the known genes that account for a portion of the familial clustering of pancreatic cancer.
KW - Familial pancreatic cancer (FPC)
KW - Genetic syndromes
KW - Genome-wide association
UR - http://www.scopus.com/inward/record.url?scp=85039738225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039738225&partnerID=8YFLogxK
U2 - 10.21037/cco.2017.12.04
DO - 10.21037/cco.2017.12.04
M3 - Review article
C2 - 29307198
AN - SCOPUS:85039738225
SN - 2304-3865
VL - 6
JO - Chinese Clinical Oncology
JF - Chinese Clinical Oncology
IS - 6
M1 - 58
ER -