Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells

Stephen B. Baylin; Susan H. Hsu; Donald S. Gann; Robert C. Smallridge; Samuel A. Wells

doi:10.1126/science.619463

Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells

Stephen B. Baylin, Susan H. Hsu, Donald S. Gann, Robert C. Smallridge, Samuel A. Wells

School of Medicine

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.

Original language	English (US)
Pages (from-to)	429-431
Number of pages	3
Journal	Science
Volume	199
Issue number	4327
DOIs	https://doi.org/10.1126/science.619463
State	Published - 1978

ASJC Scopus subject areas

General

Access to Document

10.1126/science.619463

Cite this

@article{383a1d7acaea40cd9ffefe19adb25bfd,

title = "Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells",

abstract = "Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.",

author = "Baylin, {Stephen B.} and Hsu, {Susan H.} and Gann, {Donald S.} and Smallridge, {Robert C.} and Wells, {Samuel A.}",

year = "1978",

doi = "10.1126/science.619463",

language = "English (US)",

volume = "199",

pages = "429--431",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4327",

}

TY - JOUR

T1 - Inherited medullary thyroid carcinoma

T2 - A final monoclonal mutation in one of multiple clones of susceptible cells

AU - Baylin, Stephen B.

AU - Hsu, Susan H.

AU - Gann, Donald S.

AU - Smallridge, Robert C.

AU - Wells, Samuel A.

PY - 1978

Y1 - 1978

N2 - Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.

AB - Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.

UR - http://www.scopus.com/inward/record.url?scp=0017811004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017811004&partnerID=8YFLogxK

U2 - 10.1126/science.619463

DO - 10.1126/science.619463

M3 - Article

C2 - 619463

AN - SCOPUS:0017811004

SN - 0036-8075

VL - 199

SP - 429

EP - 431

JO - Science

JF - Science

IS - 4327

ER -

Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this