Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells

Stephen B Baylin, Susan H. Hsu, Donald S. Gann, Robert C. Smallridge, Samuel A. Wells

Research output: Contribution to journalArticle

Abstract

Inherited medullary thyroid carcinomas contain one form of glucose-6-phosphate dehydrogenase (G6PD) in black female patients who are mosaic in normal tissues for G6PD types A and B. The same individual may have several tumors each containing either G6PD A or G6PD B. The data suggest that the inherited defect is an initial mutation producing multiple clones of defective cells; each tumor then arises as a final mutation in one clone of these cells.

Original languageEnglish (US)
Pages (from-to)429-431
Number of pages3
JournalScience
Volume199
Issue number4327
StatePublished - 1978

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Glucosephosphate Dehydrogenase
Clone Cells
Mutation
Neoplasms
glucose-6-phosphate dehydrogenase A-
Medullary Thyroid cancer

ASJC Scopus subject areas

  • General

Cite this

Baylin, S. B., Hsu, S. H., Gann, D. S., Smallridge, R. C., & Wells, S. A. (1978). Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells. Science, 199(4327), 429-431.

Inherited medullary thyroid carcinoma : A final monoclonal mutation in one of multiple clones of susceptible cells. / Baylin, Stephen B; Hsu, Susan H.; Gann, Donald S.; Smallridge, Robert C.; Wells, Samuel A.

In: Science, Vol. 199, No. 4327, 1978, p. 429-431.

Research output: Contribution to journalArticle

Baylin, SB, Hsu, SH, Gann, DS, Smallridge, RC & Wells, SA 1978, 'Inherited medullary thyroid carcinoma: A final monoclonal mutation in one of multiple clones of susceptible cells', Science, vol. 199, no. 4327, pp. 429-431.
Baylin, Stephen B ; Hsu, Susan H. ; Gann, Donald S. ; Smallridge, Robert C. ; Wells, Samuel A. / Inherited medullary thyroid carcinoma : A final monoclonal mutation in one of multiple clones of susceptible cells. In: Science. 1978 ; Vol. 199, No. 4327. pp. 429-431.
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