Inhalation of acid coated carbon black particles impairs alveolar macrophage phagocytosis

George J. Jakab, Robert W. Clarke, David R. Hemenway, Malinda V. Longphre, Steven R. Kleeberger, Robert Frank

Research output: Contribution to journalArticle

Abstract

A flow-past nose-only inhalation system was used for the co-exposure of mice to carbon black aerosols (CBA) and sulfur dioxide (SO2) at varying relative humidities (RH). The conversion of SO2 to sulfate (SO4-2) on the CBA, at a fixed aerosol concentration, was dependent on RH and SO2 concentration. The effect of the aerosol-gas mixture on alveolar macrophage (AM) phagocytosis was assessed three days following exposure for 4 h. Exposure to 10 mg/m3 CBA alone at low RH (10%) and high RH (85%), to 10 ppm SO2 alone at both RH, and to the mixture at low RH had no effect on AM phagocytosis. In contrast, AM phagocytosis was significantly suppressed following co-exposure at 85% RH, the only circumstance in which significant chemisorption of the gas by the aerosol and oxidation to SO4-2 occurred. The results suggest that fine carbon particles can be an effective vector for the delivery of toxic amounts of SO4-2 to the periphery of the lung.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalToxicology Letters
Volume88
Issue number1-3
DOIs
StatePublished - Nov 1996

Fingerprint

Soot
Alveolar Macrophages
Humidity
Phagocytosis
Inhalation
Aerosols
Atmospheric humidity
Acids
Gases
Sulfur Dioxide
Poisons
Chemisorption
Nose
Gas mixtures
Sulfates
Carbon
Oxidation
Lung

Keywords

  • aerosol
  • alveolar macrophages
  • carbon black
  • lung
  • particles
  • phagocytosis
  • sulfate
  • sulfuric acid

ASJC Scopus subject areas

  • Toxicology

Cite this

Jakab, G. J., Clarke, R. W., Hemenway, D. R., Longphre, M. V., Kleeberger, S. R., & Frank, R. (1996). Inhalation of acid coated carbon black particles impairs alveolar macrophage phagocytosis. Toxicology Letters, 88(1-3), 243-248. https://doi.org/10.1016/0378-4274(96)03745-9

Inhalation of acid coated carbon black particles impairs alveolar macrophage phagocytosis. / Jakab, George J.; Clarke, Robert W.; Hemenway, David R.; Longphre, Malinda V.; Kleeberger, Steven R.; Frank, Robert.

In: Toxicology Letters, Vol. 88, No. 1-3, 11.1996, p. 243-248.

Research output: Contribution to journalArticle

Jakab, GJ, Clarke, RW, Hemenway, DR, Longphre, MV, Kleeberger, SR & Frank, R 1996, 'Inhalation of acid coated carbon black particles impairs alveolar macrophage phagocytosis', Toxicology Letters, vol. 88, no. 1-3, pp. 243-248. https://doi.org/10.1016/0378-4274(96)03745-9
Jakab GJ, Clarke RW, Hemenway DR, Longphre MV, Kleeberger SR, Frank R. Inhalation of acid coated carbon black particles impairs alveolar macrophage phagocytosis. Toxicology Letters. 1996 Nov;88(1-3):243-248. https://doi.org/10.1016/0378-4274(96)03745-9
Jakab, George J. ; Clarke, Robert W. ; Hemenway, David R. ; Longphre, Malinda V. ; Kleeberger, Steven R. ; Frank, Robert. / Inhalation of acid coated carbon black particles impairs alveolar macrophage phagocytosis. In: Toxicology Letters. 1996 ; Vol. 88, No. 1-3. pp. 243-248.
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