Ingestible Sensors and Sensing Systems for Minimally Invasive Diagnosis and Monitoring: The Next Frontier in Minimally Invasive Screening

Luke A. Beardslee, George E. Banis, Sangwook Chu, Sanwei Liu, Ashley A. Chapin, Justin M. Stine, Pankaj Jay Pasricha, Reza Ghodssi

Research output: Contribution to journalArticle

Abstract

Ingestible electronic systems that are capable of embedded sensing, particularly within the gastrointestinal (GI) tract and its accessory organs, have the potential to screen for diseases that are difficult if not impossible to detect at an early stage using other means. Furthermore, these devices have the potential to (1) reduce labor and facility costs for a variety of procedures, (2) promote research for discovering new biomarker targets for associated pathologies, (3) promote the development of autonomous or semiautonomous diagnostic aids for consumers, and (4) provide a foundation for epithelially targeted therapeutic interventions. These technological advances have the potential to make disease surveillance and treatment far more effective for a variety of conditions, allowing patients to lead longer and more productive lives. This review will examine the conventional techniques, as well as ingestible sensors and sensing systems that are currently under development for use in disease screening and diagnosis for GI disorders. Design considerations, fabrication, and applications will be discussed.

Original languageEnglish (US)
Pages (from-to)891-910
Number of pages20
JournalACS sensors
Volume5
Issue number4
DOIs
StatePublished - Apr 24 2020

Keywords

  • chronic disease monitoring
  • gastrointestinal monitoring
  • ingestible capsules
  • microsystems
  • minimally invasive diagnosis
  • sensing systems
  • swallowable sensors
  • wireless electronics

ASJC Scopus subject areas

  • Bioengineering
  • Instrumentation
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes

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