Infrequent detection of human herpesvirus 6 DNA in peripheral blood mononuclear cells from multiple sclerosis patients

Michael Mayne, Jay Krishnan, Luanne Metz, Avindra Nath, Anthony Auty, Beni M. Sahai, Christopher Power

Research output: Contribution to journalArticle

Abstract

Several studies have suggested an association between human herpesvirus 6 (HHV-6) infection and multiple sclerosis. As HHV-6 is predominantly a T- cell tropic virus, we examined the frequency of detection of HHV-6 genome in peripheral blood mononuclear cells from relapsing-remitting (n = 32) and chronic progressive (n = 14) patients and from healthy (n = 17) and neurological (n = 7) controls. Two sensitive polymerase chain reaction assays were used to target different regions within the HHV-6 genome. Depending on the polymerase chain reaction assay used, the detection of HHV-6 genome ranged from 11.7 to 23.5% (controls), 3.1 to 23.0% (relapsing-remitting), and 14.2 to 28.5% (chronic progressive). Although these observations do not exclude a pathogenic role for HHV-6 in multiple sclerosis, they indicate a lack of correlation between HHV-6 infection of peripheral blood mononuclear cells and the development of multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalAnnals of Neurology
Volume44
Issue number3
DOIs
StatePublished - Sep 1998
Externally publishedYes

Fingerprint

Human Herpesvirus 6
Multiple Sclerosis
Blood Cells
DNA
Herpesviridae Infections
Genome
Polymerase Chain Reaction
Viruses
T-Lymphocytes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Infrequent detection of human herpesvirus 6 DNA in peripheral blood mononuclear cells from multiple sclerosis patients. / Mayne, Michael; Krishnan, Jay; Metz, Luanne; Nath, Avindra; Auty, Anthony; Sahai, Beni M.; Power, Christopher.

In: Annals of Neurology, Vol. 44, No. 3, 09.1998, p. 391-394.

Research output: Contribution to journalArticle

Mayne, Michael ; Krishnan, Jay ; Metz, Luanne ; Nath, Avindra ; Auty, Anthony ; Sahai, Beni M. ; Power, Christopher. / Infrequent detection of human herpesvirus 6 DNA in peripheral blood mononuclear cells from multiple sclerosis patients. In: Annals of Neurology. 1998 ; Vol. 44, No. 3. pp. 391-394.
@article{647ea8910842491597ea6740a37f9186,
title = "Infrequent detection of human herpesvirus 6 DNA in peripheral blood mononuclear cells from multiple sclerosis patients",
abstract = "Several studies have suggested an association between human herpesvirus 6 (HHV-6) infection and multiple sclerosis. As HHV-6 is predominantly a T- cell tropic virus, we examined the frequency of detection of HHV-6 genome in peripheral blood mononuclear cells from relapsing-remitting (n = 32) and chronic progressive (n = 14) patients and from healthy (n = 17) and neurological (n = 7) controls. Two sensitive polymerase chain reaction assays were used to target different regions within the HHV-6 genome. Depending on the polymerase chain reaction assay used, the detection of HHV-6 genome ranged from 11.7 to 23.5{\%} (controls), 3.1 to 23.0{\%} (relapsing-remitting), and 14.2 to 28.5{\%} (chronic progressive). Although these observations do not exclude a pathogenic role for HHV-6 in multiple sclerosis, they indicate a lack of correlation between HHV-6 infection of peripheral blood mononuclear cells and the development of multiple sclerosis.",
author = "Michael Mayne and Jay Krishnan and Luanne Metz and Avindra Nath and Anthony Auty and Sahai, {Beni M.} and Christopher Power",
year = "1998",
month = "9",
doi = "10.1002/ana.410440317",
language = "English (US)",
volume = "44",
pages = "391--394",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Infrequent detection of human herpesvirus 6 DNA in peripheral blood mononuclear cells from multiple sclerosis patients

AU - Mayne, Michael

AU - Krishnan, Jay

AU - Metz, Luanne

AU - Nath, Avindra

AU - Auty, Anthony

AU - Sahai, Beni M.

AU - Power, Christopher

PY - 1998/9

Y1 - 1998/9

N2 - Several studies have suggested an association between human herpesvirus 6 (HHV-6) infection and multiple sclerosis. As HHV-6 is predominantly a T- cell tropic virus, we examined the frequency of detection of HHV-6 genome in peripheral blood mononuclear cells from relapsing-remitting (n = 32) and chronic progressive (n = 14) patients and from healthy (n = 17) and neurological (n = 7) controls. Two sensitive polymerase chain reaction assays were used to target different regions within the HHV-6 genome. Depending on the polymerase chain reaction assay used, the detection of HHV-6 genome ranged from 11.7 to 23.5% (controls), 3.1 to 23.0% (relapsing-remitting), and 14.2 to 28.5% (chronic progressive). Although these observations do not exclude a pathogenic role for HHV-6 in multiple sclerosis, they indicate a lack of correlation between HHV-6 infection of peripheral blood mononuclear cells and the development of multiple sclerosis.

AB - Several studies have suggested an association between human herpesvirus 6 (HHV-6) infection and multiple sclerosis. As HHV-6 is predominantly a T- cell tropic virus, we examined the frequency of detection of HHV-6 genome in peripheral blood mononuclear cells from relapsing-remitting (n = 32) and chronic progressive (n = 14) patients and from healthy (n = 17) and neurological (n = 7) controls. Two sensitive polymerase chain reaction assays were used to target different regions within the HHV-6 genome. Depending on the polymerase chain reaction assay used, the detection of HHV-6 genome ranged from 11.7 to 23.5% (controls), 3.1 to 23.0% (relapsing-remitting), and 14.2 to 28.5% (chronic progressive). Although these observations do not exclude a pathogenic role for HHV-6 in multiple sclerosis, they indicate a lack of correlation between HHV-6 infection of peripheral blood mononuclear cells and the development of multiple sclerosis.

UR - http://www.scopus.com/inward/record.url?scp=0031709318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031709318&partnerID=8YFLogxK

U2 - 10.1002/ana.410440317

DO - 10.1002/ana.410440317

M3 - Article

C2 - 9749608

AN - SCOPUS:0031709318

VL - 44

SP - 391

EP - 394

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -