Infrared imaging for tumor detection using antibodies conjugated magnetic nanoparticles

Arie Levy, Israel Gannot

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Thermography is a well known approach for cost effective early detection of concourse tumors. However, till now-more than 5 decades after its introduction- it is not considered as a primary tool for cancer early detection, mainly because its poor performance compared to other techniques. This work offers a new thermographic approach for tumor detection which is based on the use of antibody conjugated magnetic nanoparticles ("MNP") as a tumor specific marker. Wename this method "Thermal Beacon Thermography" ("TBT"), and it has the potential to provide considerable advantages over conventional thermographic approach. TBT approach is based on the fact that MNP are producing heat when subjected to an alternating magnetic field ("AMF"). Once these particles are injected to the patient blood stream, they specifically accumulate at the tumor site, providing a local heat source at the tumor that can be activated and deactivated by external control. This heat source can be used as a "thermal beacon" in order to detect and locate tumor by detecting temperature changes at the skin surface using an 1R camera and comparing them to a set of pre-calculated numerical predictions. Experiments were conducted using an in vitro tissue model together with industrial inductive heating system and an IR camera. The results shows that this approach can specifically detect small tumor phantom (D=1.5mm) which was embedded below the surface of the tissue phantom.

Original languageEnglish (US)
Title of host publicationBiophotonics
Subtitle of host publicationPhotonic Solutions for Better Health Care
DOIs
StatePublished - Jun 18 2008
Externally publishedYes
EventBiophotonics: Photonic Solutions for Better Health Care - Strasbourg, France
Duration: Apr 8 2008Apr 10 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6991
ISSN (Print)1605-7422

Conference

ConferenceBiophotonics: Photonic Solutions for Better Health Care
CountryFrance
CityStrasbourg
Period4/8/084/10/08

Keywords

  • Antibody targeting
  • Magnetic nanoparticles
  • Thermography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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