Infrared atmospheric pressure MALDI ion trap mass spectrometry of frozen samples using a peltier-cooled sample stage

Christopher E. Von Seggern, Ben D. Gardner, Robert J. Cotter

Research output: Contribution to journalArticle

Abstract

Infrared atmospheric pressure matrix-assisted laser desorption/ionization on an ion trap mass spectrometer is used to analyze frozen samples generated using a Peltier-cooled sample stage. This allows for the analysis of samples in water without the addition of matrix, in near-native conditions, and with minimal loss of water due to evaporation. Analysis of frozen samples is extended to study peptides, carbohydrates, and glycolipids.

Original languageEnglish (US)
Pages (from-to)5887-5893
Number of pages7
JournalAnalytical chemistry
Volume76
Issue number19
DOIs
StatePublished - Oct 1 2004

ASJC Scopus subject areas

  • Analytical Chemistry

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