TY - GEN
T1 - Information theoretical assessment of neural spiking activity with temperature modulation
AU - Madhok, Jai
AU - Jia, Xioafeng
AU - Choi, Young Seok
AU - Zhang, Dandan
AU - Thakor, Nitish
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Previous research has shown that hypothermia immediately after Cardiac Arrest (CA) improves neurological outcomes. In order to study how hypothermia affects neural spiking, cortical and subcortical neural activity was recorded from rodents. Consistent with previous findings, preliminary results show that the firing rate is proportional to the temperature. We also studied the information coded in the spike-timing information of individual neurons and observed that information content varies with temperature. Furthermore, there is an increased dependence between the cortex and sub-cortical structures such as the Thalamus during hypothermia. The latter is most likely an indicator of coupling between these highly connected structures in response to temperature manipulation leading to arousal after global cerebral ischemia.
AB - Previous research has shown that hypothermia immediately after Cardiac Arrest (CA) improves neurological outcomes. In order to study how hypothermia affects neural spiking, cortical and subcortical neural activity was recorded from rodents. Consistent with previous findings, preliminary results show that the firing rate is proportional to the temperature. We also studied the information coded in the spike-timing information of individual neurons and observed that information content varies with temperature. Furthermore, there is an increased dependence between the cortex and sub-cortical structures such as the Thalamus during hypothermia. The latter is most likely an indicator of coupling between these highly connected structures in response to temperature manipulation leading to arousal after global cerebral ischemia.
UR - http://www.scopus.com/inward/record.url?scp=84903860031&partnerID=8YFLogxK
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U2 - 10.1109/IEMBS.2009.5334616
DO - 10.1109/IEMBS.2009.5334616
M3 - Conference contribution
C2 - 19965028
AN - SCOPUS:84903860031
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 4990
EP - 4993
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -