TY - JOUR
T1 - Information maximizing component analysis of left ventricular remodeling due to myocardial infarction
AU - Zhang, Xingyu
AU - Ambale-Venkatesh, Bharath
AU - Bluemke, David A.
AU - Cowan, Brett R.
AU - Finn, J. Paul
AU - Kadish, Alan H.
AU - Lee, Daniel C.
AU - Lima, Joao A.C.
AU - Hundley, William G.
AU - Suinesiaputra, Avan
AU - Young, Alistair A.
AU - Medrano-Gracia, Pau
N1 - Funding Information:
investigators can be found at http://www.clinicaltrials.gov. David A. Bluemke is supported by the NIH intramural research program. Xingyu Zhang would like to gratefully acknowledge financial support from the China Scholarship Council.
Funding Information:
This project was supported by award numbers R01HL087773 and R01HL121754 from the National Heart, Lung, and Blood Institute. MESA was supported by contracts N01‑HC‑95159 through N01‑HC‑95169 from the NHLBI and by grants UL1‑RR‑024156 and UL1‑RR‑025005 from NCRR. DETERMINE was supported by St. Jude Medical, Inc; and the National Heart, Lung and Blood Institute (R01HL91069). A list of participating DETERMINE
Publisher Copyright:
© 2015 Zhang et al.
PY - 2015/11/3
Y1 - 2015/11/3
N2 - Background: Although adverse left ventricular shape changes (remodeling) after myocardial infarction (MI) are predictive of morbidity and mortality, current clinical assessment is limited to simple mass and volume measures, or dimension ratios such as length to width ratio. We hypothesized that information maximizing component analysis (IMCA), a supervised feature extraction method, can provide more efficient and sensitive indices of overall remodeling. Methods: IMCA was compared to linear discriminant analysis (LDA), both supervised methods, to extract the most discriminatory global shape changes associated with remodeling after MI. Finite element shape models from 300 patients with myocardial infarction from the DETERMINE study (age 31-86, mean age 63, 20% women) were compared with 1991 asymptomatic cases from the MESA study (age 44-84, mean age 62, 52% women) available from the Cardiac Atlas Project. IMCA and LDA were each used to identify a single mode of global remodeling best discriminating the two groups. Logistic regression was employed to determine the association between the remodeling index and MI. Goodness-of-fit results were compared against a baseline logistic model comprising standard clinical indices. Results: A single IMCA mode simultaneously describing end-diastolic and end-systolic shapes achieved best results (lowest Deviance, Akaike information criterionand Bayesian information criterion, and the largest area under thereceiver-operating-characteristiccurve). This mode provided a continuous scale where remodeling can be quantified and visualized, showing that MI patients tend to present larger size and more spherical shape, more bulging of the apex, and thinner wall thickness. Conclusions: IMCA enables better characterization of global remodeling than LDA, and can be used to quantify progression of disease and the effect of treatment. These data and results are available from the Cardiac Atlas Project ( http://www.cardiacatlas.org ).
AB - Background: Although adverse left ventricular shape changes (remodeling) after myocardial infarction (MI) are predictive of morbidity and mortality, current clinical assessment is limited to simple mass and volume measures, or dimension ratios such as length to width ratio. We hypothesized that information maximizing component analysis (IMCA), a supervised feature extraction method, can provide more efficient and sensitive indices of overall remodeling. Methods: IMCA was compared to linear discriminant analysis (LDA), both supervised methods, to extract the most discriminatory global shape changes associated with remodeling after MI. Finite element shape models from 300 patients with myocardial infarction from the DETERMINE study (age 31-86, mean age 63, 20% women) were compared with 1991 asymptomatic cases from the MESA study (age 44-84, mean age 62, 52% women) available from the Cardiac Atlas Project. IMCA and LDA were each used to identify a single mode of global remodeling best discriminating the two groups. Logistic regression was employed to determine the association between the remodeling index and MI. Goodness-of-fit results were compared against a baseline logistic model comprising standard clinical indices. Results: A single IMCA mode simultaneously describing end-diastolic and end-systolic shapes achieved best results (lowest Deviance, Akaike information criterionand Bayesian information criterion, and the largest area under thereceiver-operating-characteristiccurve). This mode provided a continuous scale where remodeling can be quantified and visualized, showing that MI patients tend to present larger size and more spherical shape, more bulging of the apex, and thinner wall thickness. Conclusions: IMCA enables better characterization of global remodeling than LDA, and can be used to quantify progression of disease and the effect of treatment. These data and results are available from the Cardiac Atlas Project ( http://www.cardiacatlas.org ).
KW - Cardiac remodeling
KW - Information maximizing component analysis
KW - Linear discriminant analysis
KW - Logistic regression
KW - Magnetic resonance imaging
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U2 - 10.1186/s12967-015-0709-4
DO - 10.1186/s12967-015-0709-4
M3 - Article
C2 - 26531126
AN - SCOPUS:84946082272
SN - 1479-5876
VL - 13
JO - Journal of translational medicine
JF - Journal of translational medicine
IS - 1
M1 - 343
ER -