Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children

Lucy Chai See Lum, Charissa Fay Borja-Tabora, Robert F. Breiman, Timo Vesikari, Benjamin P. Sablan, Oh Moh Chay, Taweewong Tantracheewathorn, Heinz Josef Schmitt, Yu Lung Lau, Piyaporn Bowonkiratikachorn, John S. Tam, Bee Wah Lee, Kah Kee Tan, Jerzy Pejcz, Sungho Cha, Maricruz Gutierrez-Brito, Petras Kaltenis, Andre Vertruyen, Hanna Czajka, Jurgis BojarskasW. Abdullah Brooks, Sheau Mei Cheng, Ruth Rappaport, Sherryl Baker, William C. Gruber, Bruce D. Forrest

Research output: Contribution to journalArticlepeer-review

Abstract

Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35 ± 7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV + Priorix recipients were statistically lower at a 15 IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10 IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the overall influenza protection rate of LAIV (78.4% and 63.8% against antigenically similar influenza strains and any strain, respectively).

Original languageEnglish (US)
Pages (from-to)1566-1574
Number of pages9
JournalVaccine
Volume28
Issue number6
DOIs
StatePublished - Feb 10 2010
Externally publishedYes

Keywords

  • Combined vaccines
  • Live attenuated influenza vaccine
  • Measles-mumps-rubella vaccine
  • Vaccine interference

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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