Influenza infection in neutropenic adults

Urshila Durani, Maria V. Dioverti Prono, Pritish K. Tosh, Mrinal Patnaik, Jason N. Barreto, Aaron J. Tande

Research output: Contribution to journalArticlepeer-review

Abstract

While lymphopenia is a well-defined risk factor for severe influenza, the effect of neutropenia is unknown. This was a retrospective single centre study of adult patients with documented neutropenia and influenza between 2005 and 2013. Forty patients were included with a median follow-up of 2 years (IQR 0.8–4.0). Median ANC at influenza diagnosis was 0.3 × 109/L (IQR 0.1–0.4 × 109/L). Outcomes included hospitalization (N = 28, 70%), pneumonia (N = 9, 23%), ICU admission (N = 9, 23%) and mechanical ventilation (N = 7, 18%). Three deaths (7.5%) were attributed to influenza, all of whom had lower respiratory tract infection (LRTI). Patients with LRTI (N = 18, 45%) also had a higher 30-day mortality (37 versus 0%) and 90-day mortality (42 versus 0%) than those with upper respiratory tract infection. In summary, neutropenic patients have high rates of influenza complications. Our study highlights the need for early diagnosis and aggressive management of influenza in this population.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalInfectious Diseases
Volume49
Issue number2
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

Keywords

  • immunocompromised host
  • influenza virus
  • neutropenia
  • Respiratory tract infection

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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