Influences of the Mosquito Microbiota on Vector Competence

S. van Tol, George Dimopoulos

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mosquitoes have a diverse intestinal microbiota which plays essential roles in a variety of the insect's physiological functions. This microbiota can also influence vector competence for human pathogens in multiple ways, including immune system activation or suppression, the regulation of other physiological processes, direct inhibition of the pathogen, and competition with the pathogen for limited resources. The mosquito's intestinal microbiome is responsible for eliciting basal immune activity, which in addition to preventing overproliferation of bacteria, also acts against exogenous bacteria, fungi, parasites, and viruses. Some endogenous microorganisms directly impair pathogen infectivity or viability, independent of the mosquito, through mechanisms involving reactive oxygen species and other more stable bacteria-/fungi-produced metabolites. Other microorganisms, particularly those with entomopathogenic activity, can influence pathogen transmission by shaping mosquito population dynamics. Exploration of the mosquito gut microbiome's antipathogen and entomopathogenic activities can provide essential knowledge for the development of novel disease-control approaches based on blocking pathogen infection in the mosquito and vertebrate host and/or shortening the mosquito's lifespan.

Original languageEnglish (US)
Title of host publicationProgress in Mosquito Research, 2016
PublisherAcademic Press Inc.
Pages249-291
Number of pages43
Volume51
ISBN (Print)9780128024577
DOIs
StatePublished - 2016

Publication series

NameAdvances in Insect Physiology
Volume51
ISSN (Print)00652806
ISSN (Electronic)22136800

Keywords

  • Bacteria
  • Dengue
  • Fungi
  • Malaria
  • Microbiota
  • Mosquitoes
  • Parasites
  • Vector competence
  • Virus

ASJC Scopus subject areas

  • Insect Science

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  • Cite this

    van Tol, S., & Dimopoulos, G. (2016). Influences of the Mosquito Microbiota on Vector Competence. In Progress in Mosquito Research, 2016 (Vol. 51, pp. 249-291). (Advances in Insect Physiology; Vol. 51). Academic Press Inc.. https://doi.org/10.1016/bs.aiip.2016.04.006