Influences of neural pathway integrity on children's response to reading instruction

Nicole Davis, Qiuyun Fan, Donald L. Compton, Doug Fuchs, Lynn S. Fuchs, Laurie E. Cutting, John C. Gore, Adam W. Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

As the education field moves toward using responsiveness to intervention to identify students with disabilities, an important question is the degree to which this classification can be connected to a student's neurobiological characteristics. A few functional neuroimaging studies have reported a relationship between activation and response to instruction; however, whether a similar correlation exists with white matter (WM) is not clear. To investigate this issue, we acquired high angular resolution diffusion images from a group of first grade children who differed in their levels of responsiveness to a year-long reading intervention. Using probabilistic tractography, we calculated the strength of WM connections among nine cortical regions of interest and correlated these estimates with participants' scores on four standardized reading measures. We found eight significant correlations, four of which were connections between the insular cortex and angular gyrus. In each of the correlations, a relationship with children's response to intervention was evident.

Original languageEnglish (US)
Article number150
JournalFrontiers in Systems Neuroscience
Volume4
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Children
  • Connectivity
  • Diffusion tensor imaging
  • Magnetic resonance imaging
  • Probabilistic tractography
  • Reading disability
  • Response to intervention

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Developmental Neuroscience

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