Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart

Matthew G. Fishler, Rose A. Province, Raymond C. Chan, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A computer model to simulate the three-dimensional nature of electrical propagation through the ventricles of a heart has been developed. How the vulnerability of the heart to ventricular fibrillation (VF) is influenced by increasing degrees of localized ischemia is investigated. Vulnerability was quantified by determining the minimum number of premature stimuli required to induce VF. The premature stimuli were timed such that stimuli depolarized an ectopic site after a constant delay relative to the end of the site's absolute refractory period. It is concluded that ischemia influences the model's vulnerability to VF through two mechanisms: it globally decreases the threshold at which VF occurs, and it increases the span of time within the cardiac cycle during which the heat is susceptible to premature stimuli.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
PublisherPubl by IEEE
Pages644-645
Number of pages2
Editionpt 2
ISBN (Print)0879425598
StatePublished - 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

Fingerprint

Refractory materials
Hot Temperature

ASJC Scopus subject areas

  • Bioengineering

Cite this

Fishler, M. G., Province, R. A., Chan, R. C., & Thakor, N. V. (1990). Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart. In Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 2 ed., pp. 644-645). Publ by IEEE.

Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart. / Fishler, Matthew G.; Province, Rose A.; Chan, Raymond C.; Thakor, Nitish V.

Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2. ed. Publ by IEEE, 1990. p. 644-645.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fishler, MG, Province, RA, Chan, RC & Thakor, NV 1990, Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart. in Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 edn, Publ by IEEE, pp. 644-645, Proceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Philadelphia, PA, USA, 11/1/90.
Fishler MG, Province RA, Chan RC, Thakor NV. Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart. In Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 ed. Publ by IEEE. 1990. p. 644-645
Fishler, Matthew G. ; Province, Rose A. ; Chan, Raymond C. ; Thakor, Nitish V. / Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart. Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2. ed. Publ by IEEE, 1990. pp. 644-645
@inproceedings{fee3663441ff4a24892c8f9519d6a6f6,
title = "Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart",
abstract = "A computer model to simulate the three-dimensional nature of electrical propagation through the ventricles of a heart has been developed. How the vulnerability of the heart to ventricular fibrillation (VF) is influenced by increasing degrees of localized ischemia is investigated. Vulnerability was quantified by determining the minimum number of premature stimuli required to induce VF. The premature stimuli were timed such that stimuli depolarized an ectopic site after a constant delay relative to the end of the site's absolute refractory period. It is concluded that ischemia influences the model's vulnerability to VF through two mechanisms: it globally decreases the threshold at which VF occurs, and it increases the span of time within the cardiac cycle during which the heat is susceptible to premature stimuli.",
author = "Fishler, {Matthew G.} and Province, {Rose A.} and Chan, {Raymond C.} and Thakor, {Nitish V}",
year = "1990",
language = "English (US)",
isbn = "0879425598",
pages = "644--645",
booktitle = "Proceedings of the Annual Conference on Engineering in Medicine and Biology",
publisher = "Publ by IEEE",
edition = "pt 2",

}

TY - GEN

T1 - Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart

AU - Fishler, Matthew G.

AU - Province, Rose A.

AU - Chan, Raymond C.

AU - Thakor, Nitish V

PY - 1990

Y1 - 1990

N2 - A computer model to simulate the three-dimensional nature of electrical propagation through the ventricles of a heart has been developed. How the vulnerability of the heart to ventricular fibrillation (VF) is influenced by increasing degrees of localized ischemia is investigated. Vulnerability was quantified by determining the minimum number of premature stimuli required to induce VF. The premature stimuli were timed such that stimuli depolarized an ectopic site after a constant delay relative to the end of the site's absolute refractory period. It is concluded that ischemia influences the model's vulnerability to VF through two mechanisms: it globally decreases the threshold at which VF occurs, and it increases the span of time within the cardiac cycle during which the heat is susceptible to premature stimuli.

AB - A computer model to simulate the three-dimensional nature of electrical propagation through the ventricles of a heart has been developed. How the vulnerability of the heart to ventricular fibrillation (VF) is influenced by increasing degrees of localized ischemia is investigated. Vulnerability was quantified by determining the minimum number of premature stimuli required to induce VF. The premature stimuli were timed such that stimuli depolarized an ectopic site after a constant delay relative to the end of the site's absolute refractory period. It is concluded that ischemia influences the model's vulnerability to VF through two mechanisms: it globally decreases the threshold at which VF occurs, and it increases the span of time within the cardiac cycle during which the heat is susceptible to premature stimuli.

UR - http://www.scopus.com/inward/record.url?scp=0025551566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025551566&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0025551566

SN - 0879425598

SP - 644

EP - 645

BT - Proceedings of the Annual Conference on Engineering in Medicine and Biology

PB - Publ by IEEE

ER -