Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart

Matthew G. Fishler, Rose A. Province, Raymond C. Chan, Nitish V. Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A computer model to simulate the three-dimensional nature of electrical propagation through the ventricles of a heart has been developed. How the vulnerability of the heart to ventricular fibrillation (VF) is influenced by increasing degrees of localized ischemia is investigated. Vulnerability was quantified by determining the minimum number of premature stimuli required to induce VF. The premature stimuli were timed such that stimuli depolarized an ectopic site after a constant delay relative to the end of the site's absolute refractory period. It is concluded that ischemia influences the model's vulnerability to VF through two mechanisms: it globally decreases the threshold at which VF occurs, and it increases the span of time within the cardiac cycle during which the heat is susceptible to premature stimuli.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Pages644-645
Number of pages2
Editionpt 2
ISBN (Print)0879425598
StatePublished - Dec 1 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 2
ISSN (Print)0589-1019

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Fishler, M. G., Province, R. A., Chan, R. C., & Thakor, N. V. (1990). Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart. In Biomedical Engineering Perspectives: Health Care Technologies for the 1990's and Beyond (pt 2 ed., pp. 644-645). (Proceedings of the Annual Conference on Engineering in Medicine and Biology; No. pt 2). Publ by IEEE.