@inproceedings{fee3663441ff4a24892c8f9519d6a6f6,
title = "Influences of ischemia on ventricular fibrillation threshold and vulnerable period in a 3D computer model of a heart",
abstract = "A computer model to simulate the three-dimensional nature of electrical propagation through the ventricles of a heart has been developed. How the vulnerability of the heart to ventricular fibrillation (VF) is influenced by increasing degrees of localized ischemia is investigated. Vulnerability was quantified by determining the minimum number of premature stimuli required to induce VF. The premature stimuli were timed such that stimuli depolarized an ectopic site after a constant delay relative to the end of the site's absolute refractory period. It is concluded that ischemia influences the model's vulnerability to VF through two mechanisms: it globally decreases the threshold at which VF occurs, and it increases the span of time within the cardiac cycle during which the heat is susceptible to premature stimuli.",
author = "Fishler, {Matthew G.} and Province, {Rose A.} and Chan, {Raymond C.} and Thakor, {Nitish V.}",
year = "1990",
month = dec,
day = "1",
language = "English (US)",
isbn = "0879425598",
series = "Proceedings of the Annual Conference on Engineering in Medicine and Biology",
publisher = "Publ by IEEE",
number = "pt 2",
pages = "644--645",
booktitle = "Biomedical Engineering Perspectives",
edition = "pt 2",
note = "Proceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society ; Conference date: 01-11-1990 Through 04-11-1990",
}