Influence of tumor grade on time to progression after irradiation for localized ependymoma in children

Thomas E. Merchant, Jesse J. Jenkins, Peter C. Burger, Robert A. Sanford, Scot H. Sherwood, Dana Jones-Wallace, Richard L. Heideman, Stephen J. Thompson, Kathleen J. Helton, Larry E. Kun

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the influence of histologic grade on progression-free survival (PFS) after irradiation (RT) for pediatric patients with localized ependymoma. Methods and Materials: Fifty patients with localized ependymoma (median age 3.6 years, range 1-18 years at the time of RT) were treated with RT between December 1982 and June 1999. Anaplastic features were identified in 14 of 50 patients. The extent of resection was characterized as gross-total in 36 patients, near-total in 5, and subtotal in 9. The median dose to the primary site was 54 Gy. Of the 50 patients, 23 received pre-RT chemotherapy. Results: Thirty-nine patients were alive at a median follow-up of 46 months (range 21-214) from diagnosis. Thirty-four patients remained progression free at a median follow-up of 35 months (range 13-183) after the initiation of RT. Progression occurred in 16 patients (12 local and 4 local and distant), with a median time to failure of 21.2 months (range 4.6-65.0). The tumor grade significantly influenced the PFS after RT (p <0.0005). The estimated 3-year PFS rate was 28% ± 14% for patients with anaplastic ependymoma compared with 84% ± 8% for patients with differentiated ependymoma. These results remained significant when corrected for age at diagnosis (

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume53
Issue number1
DOIs
StatePublished - May 1 2002
Externally publishedYes

Fingerprint

Ependymoma
progressions
grade
tumors
irradiation
Neoplasms
Disease-Free Survival
chemotherapy
Survival Rate
Pediatrics
Drug Therapy

Keywords

  • Brain tumors
  • Chemotherapy
  • Ependymoma
  • Pediatrics
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Merchant, T. E., Jenkins, J. J., Burger, P. C., Sanford, R. A., Sherwood, S. H., Jones-Wallace, D., ... Kun, L. E. (2002). Influence of tumor grade on time to progression after irradiation for localized ependymoma in children. International Journal of Radiation Oncology, Biology, Physics, 53(1), 52-57. https://doi.org/10.1016/S0360-3016(01)02801-2

Influence of tumor grade on time to progression after irradiation for localized ependymoma in children. / Merchant, Thomas E.; Jenkins, Jesse J.; Burger, Peter C.; Sanford, Robert A.; Sherwood, Scot H.; Jones-Wallace, Dana; Heideman, Richard L.; Thompson, Stephen J.; Helton, Kathleen J.; Kun, Larry E.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 53, No. 1, 01.05.2002, p. 52-57.

Research output: Contribution to journalArticle

Merchant, TE, Jenkins, JJ, Burger, PC, Sanford, RA, Sherwood, SH, Jones-Wallace, D, Heideman, RL, Thompson, SJ, Helton, KJ & Kun, LE 2002, 'Influence of tumor grade on time to progression after irradiation for localized ependymoma in children', International Journal of Radiation Oncology, Biology, Physics, vol. 53, no. 1, pp. 52-57. https://doi.org/10.1016/S0360-3016(01)02801-2
Merchant, Thomas E. ; Jenkins, Jesse J. ; Burger, Peter C. ; Sanford, Robert A. ; Sherwood, Scot H. ; Jones-Wallace, Dana ; Heideman, Richard L. ; Thompson, Stephen J. ; Helton, Kathleen J. ; Kun, Larry E. / Influence of tumor grade on time to progression after irradiation for localized ependymoma in children. In: International Journal of Radiation Oncology, Biology, Physics. 2002 ; Vol. 53, No. 1. pp. 52-57.
@article{e4897e1ab5914a2bad629d8ddfef078d,
title = "Influence of tumor grade on time to progression after irradiation for localized ependymoma in children",
abstract = "Purpose: To investigate the influence of histologic grade on progression-free survival (PFS) after irradiation (RT) for pediatric patients with localized ependymoma. Methods and Materials: Fifty patients with localized ependymoma (median age 3.6 years, range 1-18 years at the time of RT) were treated with RT between December 1982 and June 1999. Anaplastic features were identified in 14 of 50 patients. The extent of resection was characterized as gross-total in 36 patients, near-total in 5, and subtotal in 9. The median dose to the primary site was 54 Gy. Of the 50 patients, 23 received pre-RT chemotherapy. Results: Thirty-nine patients were alive at a median follow-up of 46 months (range 21-214) from diagnosis. Thirty-four patients remained progression free at a median follow-up of 35 months (range 13-183) after the initiation of RT. Progression occurred in 16 patients (12 local and 4 local and distant), with a median time to failure of 21.2 months (range 4.6-65.0). The tumor grade significantly influenced the PFS after RT (p <0.0005). The estimated 3-year PFS rate was 28{\%} ± 14{\%} for patients with anaplastic ependymoma compared with 84{\%} ± 8{\%} for patients with differentiated ependymoma. These results remained significant when corrected for age at diagnosis (",
keywords = "Brain tumors, Chemotherapy, Ependymoma, Pediatrics, Radiotherapy",
author = "Merchant, {Thomas E.} and Jenkins, {Jesse J.} and Burger, {Peter C.} and Sanford, {Robert A.} and Sherwood, {Scot H.} and Dana Jones-Wallace and Heideman, {Richard L.} and Thompson, {Stephen J.} and Helton, {Kathleen J.} and Kun, {Larry E.}",
year = "2002",
month = "5",
day = "1",
doi = "10.1016/S0360-3016(01)02801-2",
language = "English (US)",
volume = "53",
pages = "52--57",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Influence of tumor grade on time to progression after irradiation for localized ependymoma in children

AU - Merchant, Thomas E.

AU - Jenkins, Jesse J.

AU - Burger, Peter C.

AU - Sanford, Robert A.

AU - Sherwood, Scot H.

AU - Jones-Wallace, Dana

AU - Heideman, Richard L.

AU - Thompson, Stephen J.

AU - Helton, Kathleen J.

AU - Kun, Larry E.

PY - 2002/5/1

Y1 - 2002/5/1

N2 - Purpose: To investigate the influence of histologic grade on progression-free survival (PFS) after irradiation (RT) for pediatric patients with localized ependymoma. Methods and Materials: Fifty patients with localized ependymoma (median age 3.6 years, range 1-18 years at the time of RT) were treated with RT between December 1982 and June 1999. Anaplastic features were identified in 14 of 50 patients. The extent of resection was characterized as gross-total in 36 patients, near-total in 5, and subtotal in 9. The median dose to the primary site was 54 Gy. Of the 50 patients, 23 received pre-RT chemotherapy. Results: Thirty-nine patients were alive at a median follow-up of 46 months (range 21-214) from diagnosis. Thirty-four patients remained progression free at a median follow-up of 35 months (range 13-183) after the initiation of RT. Progression occurred in 16 patients (12 local and 4 local and distant), with a median time to failure of 21.2 months (range 4.6-65.0). The tumor grade significantly influenced the PFS after RT (p <0.0005). The estimated 3-year PFS rate was 28% ± 14% for patients with anaplastic ependymoma compared with 84% ± 8% for patients with differentiated ependymoma. These results remained significant when corrected for age at diagnosis (

AB - Purpose: To investigate the influence of histologic grade on progression-free survival (PFS) after irradiation (RT) for pediatric patients with localized ependymoma. Methods and Materials: Fifty patients with localized ependymoma (median age 3.6 years, range 1-18 years at the time of RT) were treated with RT between December 1982 and June 1999. Anaplastic features were identified in 14 of 50 patients. The extent of resection was characterized as gross-total in 36 patients, near-total in 5, and subtotal in 9. The median dose to the primary site was 54 Gy. Of the 50 patients, 23 received pre-RT chemotherapy. Results: Thirty-nine patients were alive at a median follow-up of 46 months (range 21-214) from diagnosis. Thirty-four patients remained progression free at a median follow-up of 35 months (range 13-183) after the initiation of RT. Progression occurred in 16 patients (12 local and 4 local and distant), with a median time to failure of 21.2 months (range 4.6-65.0). The tumor grade significantly influenced the PFS after RT (p <0.0005). The estimated 3-year PFS rate was 28% ± 14% for patients with anaplastic ependymoma compared with 84% ± 8% for patients with differentiated ependymoma. These results remained significant when corrected for age at diagnosis (

KW - Brain tumors

KW - Chemotherapy

KW - Ependymoma

KW - Pediatrics

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=0036569652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036569652&partnerID=8YFLogxK

U2 - 10.1016/S0360-3016(01)02801-2

DO - 10.1016/S0360-3016(01)02801-2

M3 - Article

VL - 53

SP - 52

EP - 57

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 1

ER -