Influence of tuberculosis on human immunodeficiency virus (HIV-1): Enhanced cytokine expression and elevated β2-microglobulin in HIV-1-associated tuberculosis

Robert S. Wallis, Michael Vjecha, Manijeh Amir-Tahmasseb, Alphonse Okwera, Fred Byekwaso, Sam Nyole, Sam Kabengera, Roy D. Mugerwa, Jerrold J. Ellner

Research output: Contribution to journalArticle

Abstract

Tuberculosis results in activation of T cells and macrophages that may harbor latent human immunodeficiency virus (HIV-1). Although such activation is beneficial to the host in terms of mycobacterial disease, it may be deleterious in terms of HIV-1. In Ugandan HIV-1-seropositive patients with pulmonary tuberculosis, antigen-induced blastogenesis and production of tumor necrosis factor-α (a cytokine that induces expression of HIV-1 in latently infected cells) were 3-10 times greater than in controls. The mean serum β2-microglobulin level was 5.22 mg/L in recently diagnosed patients, significantly greater than levels in HIV-negative patients with tuberculosis or asymptomatic HIV-1-seropositive subjects. β2-microglobulin was significantly lower in subjects who had completed at least 2 months of antituberculous therapy. These observations suggest that HIV-1-associated tuberculosis is accompanied by immune activation that may result in increased HIV expression and accelerated progression to AIDS.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalJournal of Infectious Diseases
Volume167
Issue number1
StatePublished - Jan 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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    Wallis, R. S., Vjecha, M., Amir-Tahmasseb, M., Okwera, A., Byekwaso, F., Nyole, S., Kabengera, S., Mugerwa, R. D., & Ellner, J. J. (1993). Influence of tuberculosis on human immunodeficiency virus (HIV-1): Enhanced cytokine expression and elevated β2-microglobulin in HIV-1-associated tuberculosis. Journal of Infectious Diseases, 167(1), 43-48.