Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas

M. J. Glantz, P. C. Burger, J. E. Herndon, A. H. Friedman, J. G. Cairncross, N. A. Vick, S. C. Schold

Research output: Contribution to journalArticle

Abstract

Stereotactic biopsy of CNS tumors provides a small amount of tissue for pathologic diagnosis. This potentially leads to inaccurate grading of gliomas because of their histologic heterogeneity. We compared histologic diagnoses in a consecutive series of 329 patients with newly diagnosed anaplastic gliomas whose diagnoses were established by either stereotactic biopsy or open resection. Of 262 patients undergoing resection, 214 (82%) had glioblastomas and 48 (18%) had anaplastic astrocytomas (AAs). Of 67 patients undergoing stereotactic biopsy, 33 (49%) had glioblastomas and 34 (51%) had AAs. This difference suggests that some AAs diagnosed by stereotactic biopsy are actually glioblastomas and has important implications for the design and interpretation of clinical trials.

Original languageEnglish (US)
Pages (from-to)1741-1744
Number of pages4
JournalNeurology
Volume41
Issue number11
DOIs
StatePublished - Nov 1991

ASJC Scopus subject areas

  • Clinical Neurology

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    Glantz, M. J., Burger, P. C., Herndon, J. E., Friedman, A. H., Cairncross, J. G., Vick, N. A., & Schold, S. C. (1991). Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas. Neurology, 41(11), 1741-1744. https://doi.org/10.1212/wnl.41.11.1741