Influence of the Mouse Major Histocompatibility Complex, H-2, on Liver Adenylate Cyclase Activity and on Glucagon Binding to Liver Cell Membranes

The major histocompatibility complex of mice, the H-2 complex, regulates the steady-state level of adenosine cyclic 3', 5'-monophosphate (cAMP) in liver. This effect of H-2 may be due to an effect on hormone binding to receptors. Here we show that liver membranes from animals of different H-2 types differ in their sensitivity to glucagon stimulation of adenylate cyclase and in the affinity of their receptors for glucagon. No H-2-associated differences are seen in basal, NaF-stimulated, or GMP-PNP-stimulated adenylate cyclase.