Influence of study population definition on the effect of age on outcomes after blunt head trauma

Matthew E. Peters, Michael Hsu, Vani Rao, Durga Roy, Bharat R. Narapareddy, Kathleen T. Bechtold, Haris I. Sair, Timothy E. Van Meter, Hayley Falk, Anna J. Hall, Constantine G. Lyketsos, Frederick K. Korley

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objectives: The purpose of this study was to assess whether study population definition influences the effect of age on outcomes after blunt head trauma. We hypothesized that examining ‘all comers’ receiving head computerized tomography after blunt head trauma, fewer older individuals would meet Veterans Administration and Department of Defense (VA/DoD) criteria for traumatic brain injury (TBI), and would, therefore, display better outcomes than younger cohorts. However, restricting to participants meeting VA/DoD criteria for TBI, we hypothesized that older individuals would have worse outcomes. Methods: Data from a recently completed prospective cohort study were analysed with age dichotomized at 65 years. Logistic regression modelling, controlled for potential confounders including head trauma severity, was estimated to measure the effect of age on functional recovery, post-concussion symptoms (PCS), and depressive symptoms at 1-month post-TBI. Results: Fewer older than younger individuals met VA/DoD criteria for TBI. Older individuals had better functional, PCS, and depressive outcomes at 1 month. Restricting to those meeting VA/DoD criteria for TBI, older individuals continued to have better functional and PCS outcomes but had outcomes comparable to younger on depressive symptoms. Conclusions: Contrary to our hypothesis, there was a tendency for older adults to have better outcomes than younger, independent of the diagnostic criteria applied.

Original languageEnglish (US)
Pages (from-to)1725-1730
Number of pages6
JournalBrain Injury
Issue number13-14
StatePublished - Dec 6 2018


  • TBI
  • Traumatic brain injury
  • age differences
  • blunt head trauma
  • outcomes research

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental and Educational Psychology
  • Clinical Neurology


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