Influence of spatially heterogeneous background activity on 'hot object' quantitation in brain emission computed tomography

Jonathan M. Links, Jon Kar Zubieta, Carolyn Cidis Meltzer, Martin J. Stumpf, J. James Frost

Research output: Contribution to journalArticle

Abstract

Purpose: Our goal was to evaluate the influence of spatially heterogeneous background activity on 'hot object' quantitation in brain emission CT. Method: We studied the effects of spatially heterogeneous background activity on hot object quantitative recovery in simulations of both spheres and realistic brain distributions (utilizing human MRI data). Results: Significant underestimation of object activity concentration was seen for both cortical and subcortical hot objects, with increasing underestimation for increasing hot object/surrounding gray matter contrast. Significant 'spill-in' of counts from surrounding activity was present. Conclusion: Hot objects are significantly influenced by both 'spill-out' and 'spill-in.' Qualitative and quantitative analyses of such objects must explicitly consider both spill-out and spill-in; this implies a correction scheme that goes beyond simple division of the observed value by a conventional recovery coefficient.

Original languageEnglish (US)
Pages (from-to)680-687
Number of pages8
JournalJournal of computer assisted tomography
Volume20
Issue number4
DOIs
StatePublished - Jul 1 1996

Keywords

  • Magnetic resonance imaging, physics and instrumentation
  • Quantitation
  • Recovery coefficients

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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