Influence of sedentary behavior, physical activity, and cardiorespiratory fitness on the atherogenic index of plasma

Meghan K. Edwards, Michael Blaha, Paul D. Loprinzi

Research output: Contribution to journalArticlepeer-review


Background: Atherogenic index of plasma (AIP), calculated as LOG10 (triglycerides/high-density lipoprotein-cholesterol), may have greater utility over other metrics in predicting risk for cardiovascular disease (CVD). Previous work demonstrates the associations of physical activity (PA), sedentary behavior, and cardiorespiratory fitness (CRF) with triglycerides high-density lipoprotein (HDL-C) and CVD. Objective: Limited research has examined these parameters and their potential additive associations with AIP, which was the purpose of this study. Methods: Data from the 2003-2004 National Health and Nutrition Examination Survey (NHANES) were used (N = 307 adults 20-49 years). Sedentary behavior and moderate-to-vigorous physical activity (MVPA) were assessed via accelerometry. CRF was assessed via submaximal treadmill testing. Using median values, a PACS (Physical Activity Cardiorespiratory Sedentary) score (ranging from 0-3) was created, indicating the number of these positive characteristics (eg, above median CRF) each participant possessed. Results: Above median MVPA was associated with significantly lower AIP values (β = -0.09; 95% CI, -0.17 to -0.01; . P = .03), whereas above-median CRF (β = -0.0009; 95% CI, -0.09 to 0.08; . P = .98) and below-median sedentary behavior (β = -0.02; 95% CI, -0.13 to 0.08; . P = .60) were not. Compared to those with a PACS score of 0, those with a score of 1 or 2 did not have significantly reduced AIP values (β = 0.02; 95% CI, -0.06 to 0.10; . P = .59, and β = 0.007; 95% CI, -0.12 to 0.13; . P = .90, respectively); however, those with a score of 3 did (β = -0.14; 95% CI, -0.28 to -0.001; . P = .04). Conclusion: Interventions targeting improvements in lipid profile (AIP) may wish to promote adequate MVPA over CRF or decreased sedentary behavior.

Original languageEnglish (US)
JournalJournal of Clinical Lipidology
StateAccepted/In press - Jul 28 2016


  • Cardiovascular disease
  • Epidemiology
  • High-density lipoprotein
  • Lipid profile
  • Triglycerides

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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