Influence of radical prostatectomy on serum hormone levels

Research output: Contribution to journalArticle

Abstract

Purpose: The influence of radical prostatectomy on the hypothalamic pituitary axis has not been well studied. It is also unclear how alterations in serum androgen levels that result from surgical removal of the prostate might influence the recovery of libido and sexual function following radical prostatectomy. We determined the influence of radical prostatectomy on the hypothalamic pituitary testicular axis of 63 men with clinically localized prostate cancer treated only with radical prostatectomy. Materials and Methods: A total of 63 healthy men 43 to 67 years old were enrolled in this prospective study. Phlebotomy was performed immediately before and 1 year following radical retropubic prostatectomy. Sera were stored frozen and analyzed as a group at the end of the study. We measured serum testosterone, percent free testosterone, dihydrotestosterone (DHT), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone binding globulin and prolactin. Results: Following radical prostatectomy there was a statistically significant increase in serum testosterone, free testosterone, estradiol, LH and FSH (p

Original languageEnglish (US)
Pages (from-to)449-453
Number of pages5
JournalJournal of Urology
Volume160
Issue number2
DOIs
StatePublished - Aug 1998

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Prostatectomy
Hormones
Testosterone
Serum
Follicle Stimulating Hormone
Luteinizing Hormone
Estradiol
Libido
Sex Hormone-Binding Globulin
Phlebotomy
Dihydrotestosterone
Prolactin
Androgens
Prostate
Prostatic Neoplasms
Prospective Studies

Keywords

  • Gonadotropins
  • Hormones
  • Prostate-specific antigen
  • Prostatectomy
  • Testosterone

ASJC Scopus subject areas

  • Urology

Cite this

Influence of radical prostatectomy on serum hormone levels. / Miller, Leslie R.; Partin, Alan Wayne; Chan, Daniel Wan-Yui; Bruzek, Debra J.; Dobs, Adrian S; Epstein, Jonathan Ira; Walsh, Patrick.

In: Journal of Urology, Vol. 160, No. 2, 08.1998, p. 449-453.

Research output: Contribution to journalArticle

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AU - Epstein, Jonathan Ira

AU - Walsh, Patrick

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N2 - Purpose: The influence of radical prostatectomy on the hypothalamic pituitary axis has not been well studied. It is also unclear how alterations in serum androgen levels that result from surgical removal of the prostate might influence the recovery of libido and sexual function following radical prostatectomy. We determined the influence of radical prostatectomy on the hypothalamic pituitary testicular axis of 63 men with clinically localized prostate cancer treated only with radical prostatectomy. Materials and Methods: A total of 63 healthy men 43 to 67 years old were enrolled in this prospective study. Phlebotomy was performed immediately before and 1 year following radical retropubic prostatectomy. Sera were stored frozen and analyzed as a group at the end of the study. We measured serum testosterone, percent free testosterone, dihydrotestosterone (DHT), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone binding globulin and prolactin. Results: Following radical prostatectomy there was a statistically significant increase in serum testosterone, free testosterone, estradiol, LH and FSH (p

AB - Purpose: The influence of radical prostatectomy on the hypothalamic pituitary axis has not been well studied. It is also unclear how alterations in serum androgen levels that result from surgical removal of the prostate might influence the recovery of libido and sexual function following radical prostatectomy. We determined the influence of radical prostatectomy on the hypothalamic pituitary testicular axis of 63 men with clinically localized prostate cancer treated only with radical prostatectomy. Materials and Methods: A total of 63 healthy men 43 to 67 years old were enrolled in this prospective study. Phlebotomy was performed immediately before and 1 year following radical retropubic prostatectomy. Sera were stored frozen and analyzed as a group at the end of the study. We measured serum testosterone, percent free testosterone, dihydrotestosterone (DHT), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone binding globulin and prolactin. Results: Following radical prostatectomy there was a statistically significant increase in serum testosterone, free testosterone, estradiol, LH and FSH (p

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