Influence of Purkinje-muscle coupling on EAD development

A simulation study

M. Monserrat, J. Saiz, J. M. Ferrero, V. Torres, J. M. Ferrero, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Early afterdepolarizations (EADs) are irregularities that occur during the repolarization phase of the action potential (AP) interrupting or delaying normal repolarization. In this work, computer simulations have been used to study the influence of Purkinje-muscle coupling on EADs generated in Purkinje cells. The electrical behaviour of the ventricular (v) and Purkinje (P) cells have been simulated using the Luo-Rudy phase II model and the DiFrancesco-Noble equations, respectively. EADs were induced in the P cells by enhancing the Ca2+ current through the L-type channels and partially blocking the delayed rectifying K+ current. Our results suggest that the P-V connection reduces the likelihood of appearance of EADs in Purkinje fibers (PFs). Moreover, when FADs occur in P cells, there is a range of coupling values that allows their propagation as APs to the V cells.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherIEEE Comp Soc
Pages513-516
Number of pages4
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden
Duration: Sep 7 1997Sep 10 1997

Other

OtherProceedings of the 1997 24th Annual Meeting on Computers in Cardiology
CityLund, Sweden
Period9/7/979/10/97

Fingerprint

Muscle
Purkinje Cells
Muscles
Fibers
Computer simulation
Purkinje Fibers
Flavin-Adenine Dinucleotide
Computer Simulation
Action Potentials

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Monserrat, M., Saiz, J., Ferrero, J. M., Torres, V., Ferrero, J. M., & Thakor, N. V. (1997). Influence of Purkinje-muscle coupling on EAD development: A simulation study. In Computers in Cardiology (pp. 513-516). IEEE Comp Soc.

Influence of Purkinje-muscle coupling on EAD development : A simulation study. / Monserrat, M.; Saiz, J.; Ferrero, J. M.; Torres, V.; Ferrero, J. M.; Thakor, Nitish V.

Computers in Cardiology. IEEE Comp Soc, 1997. p. 513-516.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Monserrat, M, Saiz, J, Ferrero, JM, Torres, V, Ferrero, JM & Thakor, NV 1997, Influence of Purkinje-muscle coupling on EAD development: A simulation study. in Computers in Cardiology. IEEE Comp Soc, pp. 513-516, Proceedings of the 1997 24th Annual Meeting on Computers in Cardiology, Lund, Sweden, 9/7/97.
Monserrat M, Saiz J, Ferrero JM, Torres V, Ferrero JM, Thakor NV. Influence of Purkinje-muscle coupling on EAD development: A simulation study. In Computers in Cardiology. IEEE Comp Soc. 1997. p. 513-516
Monserrat, M. ; Saiz, J. ; Ferrero, J. M. ; Torres, V. ; Ferrero, J. M. ; Thakor, Nitish V. / Influence of Purkinje-muscle coupling on EAD development : A simulation study. Computers in Cardiology. IEEE Comp Soc, 1997. pp. 513-516
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