Abstract
OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community-acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case-fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty-eight individuals had received 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P =.04). Overall case-fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case-fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes ofvaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1711-1716 |
| Number of pages | 6 |
| Journal | Journal of the American Geriatrics Society |
| Volume | 59 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2011 |
| Externally published | Yes |
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Keywords
- Community-acquired pneumonia
- Influenza vaccination
- Pneumococcal vaccination
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Influence of prior pneumococcal and influenza vaccination on outcomes of older adults with community-acquired pneumonia. / Manzur, Adriana; Izquierdo, Conchita; Ruiz, Laura; Sousa, Dolores; Bayas, Jose María; Celorrio, Jose Miguel; Varona, Wenceslao; Nebot, Manel; Salleras, Lluis; Domínguez, Angela; Carratalà, Jordi.
In: Journal of the American Geriatrics Society, Vol. 59, No. 9, 09.2011, p. 1711-1716.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of prior pneumococcal and influenza vaccination on outcomes of older adults with community-acquired pneumonia
AU - Manzur, Adriana
AU - Izquierdo, Conchita
AU - Ruiz, Laura
AU - Sousa, Dolores
AU - Bayas, Jose María
AU - Celorrio, Jose Miguel
AU - Varona, Wenceslao
AU - Nebot, Manel
AU - Salleras, Lluis
AU - Domínguez, Angela
AU - Carratalà, Jordi
PY - 2011/9
Y1 - 2011/9
N2 - OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community-acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case-fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty-eight individuals had received 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P =.04). Overall case-fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case-fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes ofvaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.
AB - OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community-acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case-fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty-eight individuals had received 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P =.04). Overall case-fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case-fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes ofvaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.
KW - Community-acquired pneumonia
KW - Influenza vaccination
KW - Pneumococcal vaccination
UR - http://www.scopus.com/inward/record.url?scp=80054746881&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054746881&partnerID=8YFLogxK
U2 - 10.1111/j.1532-5415.2011.03541.x
DO - 10.1111/j.1532-5415.2011.03541.x
M3 - Article
C2 - 21806565
AN - SCOPUS:80054746881
VL - 59
SP - 1711
EP - 1716
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
IS - 9
ER -