Influence of prior pneumococcal and influenza vaccination on outcomes of older adults with community-acquired pneumonia

Adriana Manzur, Conchita Izquierdo, Laura Ruiz, Dolores Sousa, Jose María Bayas, Jose Miguel Celorrio, Wenceslao Varona, Manel Nebot, Lluis Salleras, Angela Domínguez, Jordi Carratalà

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community-acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case-fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty-eight individuals had received 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P =.04). Overall case-fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case-fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes ofvaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.

Original languageEnglish (US)
Pages (from-to)1711-1716
Number of pages6
JournalJournal of the American Geriatrics Society
Volume59
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

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Human Influenza
Length of Stay
Pneumonia
Vaccination
Intensive Care Units
Mortality
Social Adjustment
Pneumococcal Vaccines
Public Hospitals
Group Psychotherapy
Multicenter Studies
Observational Studies
Hospital Emergency Service
Vaccines
Outcome Assessment (Health Care)
Anti-Bacterial Agents
Population

Keywords

  • Community-acquired pneumonia
  • Influenza vaccination
  • Pneumococcal vaccination

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Influence of prior pneumococcal and influenza vaccination on outcomes of older adults with community-acquired pneumonia. / Manzur, Adriana; Izquierdo, Conchita; Ruiz, Laura; Sousa, Dolores; Bayas, Jose María; Celorrio, Jose Miguel; Varona, Wenceslao; Nebot, Manel; Salleras, Lluis; Domínguez, Angela; Carratalà, Jordi.

In: Journal of the American Geriatrics Society, Vol. 59, No. 9, 09.2011, p. 1711-1716.

Research output: Contribution to journalArticle

Manzur, A, Izquierdo, C, Ruiz, L, Sousa, D, Bayas, JM, Celorrio, JM, Varona, W, Nebot, M, Salleras, L, Domínguez, A & Carratalà, J 2011, 'Influence of prior pneumococcal and influenza vaccination on outcomes of older adults with community-acquired pneumonia', Journal of the American Geriatrics Society, vol. 59, no. 9, pp. 1711-1716. https://doi.org/10.1111/j.1532-5415.2011.03541.x
Manzur, Adriana ; Izquierdo, Conchita ; Ruiz, Laura ; Sousa, Dolores ; Bayas, Jose María ; Celorrio, Jose Miguel ; Varona, Wenceslao ; Nebot, Manel ; Salleras, Lluis ; Domínguez, Angela ; Carratalà, Jordi. / Influence of prior pneumococcal and influenza vaccination on outcomes of older adults with community-acquired pneumonia. In: Journal of the American Geriatrics Society. 2011 ; Vol. 59, No. 9. pp. 1711-1716.
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AU - Manzur, Adriana

AU - Izquierdo, Conchita

AU - Ruiz, Laura

AU - Sousa, Dolores

AU - Bayas, Jose María

AU - Celorrio, Jose Miguel

AU - Varona, Wenceslao

AU - Nebot, Manel

AU - Salleras, Lluis

AU - Domínguez, Angela

AU - Carratalà, Jordi

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Y1 - 2011/9

N2 - OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community-acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case-fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty-eight individuals had received 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P =.04). Overall case-fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case-fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes ofvaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.

AB - OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community-acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case-fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty-eight individuals had received 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P =.04). Overall case-fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case-fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes ofvaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.

KW - Community-acquired pneumonia

KW - Influenza vaccination

KW - Pneumococcal vaccination

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