Influence of parathyroid hormone and calcitonin on tissue zinc homeostasis in the rat

A. B. Chausmer; M. D. Stevens; R. Zears

doi:10.1016/0026-0495(80)90105-5

Influence of parathyroid hormone and calcitonin on tissue zinc homeostasis in the rat

A. B. Chausmer, M. D. Stevens, R. Zears

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Tissue zinc accumulation kinetics and compartmental analysis models were evaluated in thyroparathyroidectomized (TPTX) rats treated with parathyroid extract or calcitonin. The animals were injected with ⁶⁵Zn and studied at multiple time intervals. SAAM-25 was utilized to generate models from the plasma specific activity decay curves. Calcitonin had a marked effect to decrease the fractional influx and efflux transfer coefficients in the model and inhibit tissue zinc accumulation in several, but not all, tissues. Parathyroid extract increased accumulation in all tissuesstudied, but had minimal effects on the model. It is concluded that parathyroid hormone acts nonspecifically and that calcitonin appears to have specific influences on zinc homeostasis.

Original language	English (US)
Pages (from-to)	617-623
Number of pages	7
Journal	Metabolism
Volume	29
Issue number	7
DOIs	https://doi.org/10.1016/0026-0495(80)90105-5
State	Published - Jul 1980
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1016/0026-0495(80)90105-5

Cite this

@article{dd8402634e754734b5667de0337a4712,

title = "Influence of parathyroid hormone and calcitonin on tissue zinc homeostasis in the rat",

abstract = "Tissue zinc accumulation kinetics and compartmental analysis models were evaluated in thyroparathyroidectomized (TPTX) rats treated with parathyroid extract or calcitonin. The animals were injected with 65Zn and studied at multiple time intervals. SAAM-25 was utilized to generate models from the plasma specific activity decay curves. Calcitonin had a marked effect to decrease the fractional influx and efflux transfer coefficients in the model and inhibit tissue zinc accumulation in several, but not all, tissues. Parathyroid extract increased accumulation in all tissuesstudied, but had minimal effects on the model. It is concluded that parathyroid hormone acts nonspecifically and that calcitonin appears to have specific influences on zinc homeostasis.",

author = "Chausmer, {A. B.} and Stevens, {M. D.} and R. Zears",

year = "1980",

month = jul,

doi = "10.1016/0026-0495(80)90105-5",

language = "English (US)",

volume = "29",

pages = "617--623",

journal = "Metabolism",

issn = "0026-0495",

publisher = "W.B. Saunders Ltd",

number = "7",

}

TY - JOUR

T1 - Influence of parathyroid hormone and calcitonin on tissue zinc homeostasis in the rat

AU - Chausmer, A. B.

AU - Stevens, M. D.

AU - Zears, R.

PY - 1980/7

Y1 - 1980/7

N2 - Tissue zinc accumulation kinetics and compartmental analysis models were evaluated in thyroparathyroidectomized (TPTX) rats treated with parathyroid extract or calcitonin. The animals were injected with 65Zn and studied at multiple time intervals. SAAM-25 was utilized to generate models from the plasma specific activity decay curves. Calcitonin had a marked effect to decrease the fractional influx and efflux transfer coefficients in the model and inhibit tissue zinc accumulation in several, but not all, tissues. Parathyroid extract increased accumulation in all tissuesstudied, but had minimal effects on the model. It is concluded that parathyroid hormone acts nonspecifically and that calcitonin appears to have specific influences on zinc homeostasis.

AB - Tissue zinc accumulation kinetics and compartmental analysis models were evaluated in thyroparathyroidectomized (TPTX) rats treated with parathyroid extract or calcitonin. The animals were injected with 65Zn and studied at multiple time intervals. SAAM-25 was utilized to generate models from the plasma specific activity decay curves. Calcitonin had a marked effect to decrease the fractional influx and efflux transfer coefficients in the model and inhibit tissue zinc accumulation in several, but not all, tissues. Parathyroid extract increased accumulation in all tissuesstudied, but had minimal effects on the model. It is concluded that parathyroid hormone acts nonspecifically and that calcitonin appears to have specific influences on zinc homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=0018860844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018860844&partnerID=8YFLogxK

U2 - 10.1016/0026-0495(80)90105-5

DO - 10.1016/0026-0495(80)90105-5

M3 - Article

C2 - 7382826

AN - SCOPUS:0018860844

SN - 0026-0495

VL - 29

SP - 617

EP - 623

JO - Metabolism

JF - Metabolism

IS - 7

ER -

Influence of parathyroid hormone and calcitonin on tissue zinc homeostasis in the rat

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this