Influence of oral contraceptive use and cigarette smoking alone and together, on antipyrine pharmacokinetics

Joseph M. Scavone, David J. Greenblatt, Darrell R. Abernethy, Becki G. Luna, Jerold S. Harmatz, Richard I. Shader

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of antipyrine following a single 1-g intravenous dose was determined in 63 healthy women. Subjects were divided into 4 groups as follows: 1) cigarette smokers using low-dose oral contraceptives (n = 15); 2) nonsmokers using low-dose oral contraceptives (n = 12); 3) cigarette smokers not using oral contraceptives (n = 10); and 4) controls, neither cigarette smokers nor oral contraceptive users. Plasma antipyrine concentrations during 24 to 48 hours after dosage were measured by high- performance liquid chromatography. Mean kinetic variables in the nonsmoking, non-oral contraceptive using control group were: volume of distribution, 37.7 L; elimination half-life, 13.2 hours; and clearance, 34.4 mL/min. In cigarette smoking, non-oral contraceptive users versus controls, elimination half-life was reduced (8.0 vs. 13.2 hours, P

Original languageEnglish (US)
Pages (from-to)437-441
Number of pages5
JournalJournal of Clinical Pharmacology
Volume37
Issue number5
Publication statusPublished - May 1997
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Scavone, J. M., Greenblatt, D. J., Abernethy, D. R., Luna, B. G., Harmatz, J. S., & Shader, R. I. (1997). Influence of oral contraceptive use and cigarette smoking alone and together, on antipyrine pharmacokinetics. Journal of Clinical Pharmacology, 37(5), 437-441.