Influence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens

L. D. Bacon; N. R. Rose

doi:10.1073/pnas.76.3.1435

Influence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens

L. D. Bacon, N. R. Rose

Research output: Contribution to journal › Article › peer-review

Abstract

Three partially inbred substrains of obese strain chickens were studied for the spontaneous development of autoimmune thyroiditis. The influence of the major histocompatibility complex (B haplotype) was marked in 1, less marked but still significant in a 2nd, and barely detectable and transient in a third substrain. These differences in the effect of B haplotype may be due to the overriding action of genes other than those within the B haplotype.

Original language	English (US)
Pages (from-to)	1435-1437
Number of pages	3
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	76
Issue number	3
DOIs	https://doi.org/10.1073/pnas.76.3.1435
State	Published - 1979
Externally published	Yes

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title = "Influence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens",

abstract = "Three partially inbred substrains of obese strain chickens were studied for the spontaneous development of autoimmune thyroiditis. The influence of the major histocompatibility complex (B haplotype) was marked in 1, less marked but still significant in a 2nd, and barely detectable and transient in a third substrain. These differences in the effect of B haplotype may be due to the overriding action of genes other than those within the B haplotype.",

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AB - Three partially inbred substrains of obese strain chickens were studied for the spontaneous development of autoimmune thyroiditis. The influence of the major histocompatibility complex (B haplotype) was marked in 1, less marked but still significant in a 2nd, and barely detectable and transient in a third substrain. These differences in the effect of B haplotype may be due to the overriding action of genes other than those within the B haplotype.

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Influence of major histocompatibility haplotype on autoimmune disease varies in different inbred families of chickens

Abstract

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