Influence of labetalol on cocaine-induced coronary vasoconstriction in humans

James D. Boehrer, David J. Moliterno, John E. Willard, L. David Hillis, Richard A. Lange

Research output: Contribution to journalArticle

Abstract

purpose: Although labetalol is sometimes given to patients with cocaine-associated chest pain, its influence on cocaine-induced coronary vasoconstriction is unknown. patients and methods: In 15 patients (7 men, 8 women, aged 40 to 79 years) undergoing catheterization for chest pain, heart rate, mean arterial pressure, and coronary arterial area (by computer-assisted quantitative angiography) were measured (1) at baseline, (2) 15 minutes after intranasal cocaine, 2 mg/kg, then (3) 5 minutes after intravenous saline (n = 6) or labetalol, 0.25 mg/kg (n = 9). results: Of 40 coronary arterial segments analyzed, cocaine induced a 13% ± 10% (mean ± standard deviation) decrease in coronary arterial area in 32. Subsequently, no variable changed after saline administration. Although labetalol reduced mean arterial pressure (117 ± 14 mm Hg after cocaine, 110 ± 11 mm Hg after labetalol; p <0.05), it induced no change in the coronary arterial area (3.47 ± 1.37 mm2 after cocaine, 3.37 ± 1.32 mm2 after labetalol; p = NS). conclusion: Labetalol reverses the cocaine-induced rise in mean arterial pressure, but does not alleviate cocaine-induced coronary vasoconstriction.

Original languageEnglish (US)
Pages (from-to)608-610
Number of pages3
JournalAmerican Journal of Medicine
Volume94
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

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Labetalol
Vasoconstriction
Cocaine
Arterial Pressure
Chest Pain
Catheterization
Angiography
Heart Rate

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Boehrer, J. D., Moliterno, D. J., Willard, J. E., Hillis, L. D., & Lange, R. A. (1993). Influence of labetalol on cocaine-induced coronary vasoconstriction in humans. American Journal of Medicine, 94(6), 608-610. https://doi.org/10.1016/0002-9343(93)90212-8

Influence of labetalol on cocaine-induced coronary vasoconstriction in humans. / Boehrer, James D.; Moliterno, David J.; Willard, John E.; Hillis, L. David; Lange, Richard A.

In: American Journal of Medicine, Vol. 94, No. 6, 1993, p. 608-610.

Research output: Contribution to journalArticle

Boehrer, JD, Moliterno, DJ, Willard, JE, Hillis, LD & Lange, RA 1993, 'Influence of labetalol on cocaine-induced coronary vasoconstriction in humans', American Journal of Medicine, vol. 94, no. 6, pp. 608-610. https://doi.org/10.1016/0002-9343(93)90212-8
Boehrer, James D. ; Moliterno, David J. ; Willard, John E. ; Hillis, L. David ; Lange, Richard A. / Influence of labetalol on cocaine-induced coronary vasoconstriction in humans. In: American Journal of Medicine. 1993 ; Vol. 94, No. 6. pp. 608-610.
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