TY - JOUR
T1 - Influence of hypoxic-preconditioning on autonomic regulation following global ischemic brain injury in rats
AU - Wu, Wenqing
AU - Guo, Xiaoli
AU - Jiang, Dineng
AU - Sun, Junfeng
AU - Qiu, Yihong
AU - Zhu, Yisheng
AU - Thakor, Nitish V.
AU - Tong, Shanbao
N1 - Funding Information:
This work was supported in part by the National Natural Science Foundation of China (No. 60601012 and No. 60671058). S. Tong is also supported by the Science and Technology Commission of the Shanghai Municipality (No. 07ZR14054) and the Shanghai Shuguang Program. We are grateful to Miss Yingying Tang for discussions on manuscript preparation and statistical analysis.
PY - 2010/8
Y1 - 2010/8
N2 - Experimental and clinical studies have shown that autonomic imbalance is associated with morbidity and mortality due to global ischemic brain injury following cardiac arrest (CA). Although hypoxic-preconditioning (HP) has shown promising neuro-protection in the subsequent ischemic brain injury, the underlying mechanisms and its influence on autonomic regulation have not yet well-understood. In this study, we utilized baroreflex sensitivity (BRS) to investigate the protective effect of HP on autonomic regulation. We investigated changes in heart rate, arterial blood pressure (BP), and BRS within 4. h after CA in rats. The relationship between BRS and neurodeficit score (NDS) was analyzed. Although no significant differences were found in heart rate and BP before and after CA between the control and the preconditioned groups, both BRS and NDS of preconditioned rats were clearly higher than that of the control rats during recovery after CA. Furthermore, BRS in the first 4. h after CA highly correlated with NDS 24. h after CA. These results imply that treatment with HP improves autonomic regulation and protects the brain from ischemic injury. The correlation between BRS and NDS also suggests that BRS can be a prognostic criterion for the level of brain injury after CA.
AB - Experimental and clinical studies have shown that autonomic imbalance is associated with morbidity and mortality due to global ischemic brain injury following cardiac arrest (CA). Although hypoxic-preconditioning (HP) has shown promising neuro-protection in the subsequent ischemic brain injury, the underlying mechanisms and its influence on autonomic regulation have not yet well-understood. In this study, we utilized baroreflex sensitivity (BRS) to investigate the protective effect of HP on autonomic regulation. We investigated changes in heart rate, arterial blood pressure (BP), and BRS within 4. h after CA in rats. The relationship between BRS and neurodeficit score (NDS) was analyzed. Although no significant differences were found in heart rate and BP before and after CA between the control and the preconditioned groups, both BRS and NDS of preconditioned rats were clearly higher than that of the control rats during recovery after CA. Furthermore, BRS in the first 4. h after CA highly correlated with NDS 24. h after CA. These results imply that treatment with HP improves autonomic regulation and protects the brain from ischemic injury. The correlation between BRS and NDS also suggests that BRS can be a prognostic criterion for the level of brain injury after CA.
KW - Autonomic nervous system
KW - Baroreflex sensitivity
KW - Cardiac arrest
KW - Hypoxic-preconditioning
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U2 - 10.1016/j.neulet.2010.06.029
DO - 10.1016/j.neulet.2010.06.029
M3 - Article
C2 - 20561564
AN - SCOPUS:77954959356
SN - 0304-3940
VL - 480
SP - 191
EP - 195
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -