Influence of hydrophobic surface modification of chitosan based methotrexate (MTX) micro implants to treat intraocular lymphoma

Soumyarwit Manna, James J. Augsburger, Zelia M. Correa, Julio A. Landero, Rupak K. Banerjee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Primary intraocular lymphoma (PIOL) is a rare form of lymphoma which is encountered in ocular oncology practice. Most preferred treatment has been intravitreal MTX injections which do not have a long lasting chemotherapeutic effect due to rapid elimination of the drug. In this study, chitosan (CS) and polylactic acid (PLA) based intraocular implants are fabricated for different MTX loadings (10%, 25% and 40% w/w). The implants administer a therapeutic dosage of 0.2-2.0 μg/day of MTX over a period of a month. PLA coated CS-MTX implants can be used for sustained release of MTX, thereby improving the treatment of PIOL.

Original languageEnglish (US)
Title of host publicationASME 2013 Summer Bioengineering Conference, SBC 2013
DOIs
StatePublished - Dec 1 2013
Externally publishedYes
EventASME 2013 Summer Bioengineering Conference, SBC 2013 - Sunriver, OR, United States
Duration: Jun 26 2013Jun 29 2013

Publication series

NameASME 2013 Summer Bioengineering Conference, SBC 2013
Volume1 B

Other

OtherASME 2013 Summer Bioengineering Conference, SBC 2013
CountryUnited States
CitySunriver, OR
Period6/26/136/29/13

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Mechanical Engineering

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    Manna, S., Augsburger, J. J., Correa, Z. M., Landero, J. A., & Banerjee, R. K. (2013). Influence of hydrophobic surface modification of chitosan based methotrexate (MTX) micro implants to treat intraocular lymphoma. In ASME 2013 Summer Bioengineering Conference, SBC 2013 (ASME 2013 Summer Bioengineering Conference, SBC 2013; Vol. 1 B). https://doi.org/10.1115/SBC2013-14414