Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats

F. Elferink, W. J F Van Der Vijgh, S. E J M Van Der Poort, S. C. Henzen-Logmans, H. M. Pinedo

Research output: Contribution to journalArticle

Abstract

Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalCancer Letters
Volume25
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

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Hydrolysis
spiroplatin
Platinum
Proteinuria
Cisplatin
Body Weight
Ligands
Glucose
sodium sulfate

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Biology

Cite this

Elferink, F., Van Der Vijgh, W. J. F., Van Der Poort, S. E. J. M., Henzen-Logmans, S. C., & Pinedo, H. M. (1984). Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats. Cancer Letters, 25(1), 61-69. https://doi.org/10.1016/S0304-3835(84)80027-0

Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats. / Elferink, F.; Van Der Vijgh, W. J F; Van Der Poort, S. E J M; Henzen-Logmans, S. C.; Pinedo, H. M.

In: Cancer Letters, Vol. 25, No. 1, 1984, p. 61-69.

Research output: Contribution to journalArticle

Elferink, F, Van Der Vijgh, WJF, Van Der Poort, SEJM, Henzen-Logmans, SC & Pinedo, HM 1984, 'Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats', Cancer Letters, vol. 25, no. 1, pp. 61-69. https://doi.org/10.1016/S0304-3835(84)80027-0
Elferink, F. ; Van Der Vijgh, W. J F ; Van Der Poort, S. E J M ; Henzen-Logmans, S. C. ; Pinedo, H. M. / Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats. In: Cancer Letters. 1984 ; Vol. 25, No. 1. pp. 61-69.
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AU - Henzen-Logmans, S. C.

AU - Pinedo, H. M.

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