Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats

F. Elferink; W. J F Van Der Vijgh; S. E J M Van Der Poort; S. C. Henzen-Logmans; H. M. Pinedo

doi:10.1016/S0304-3835(84)80027-0

Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats

F. Elferink, W. J F Van Der Vijgh, S. E J M Van Der Poort, S. C. Henzen-Logmans, H. M. Pinedo

Research output: Contribution to journal › Article › peer-review

Abstract

Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.

Original language	English (US)
Pages (from-to)	61-69
Number of pages	9
Journal	Cancer Letters
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(84)80027-0
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Oncology
Molecular Biology

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title = "Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats",

abstract = "Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.",

author = "F. Elferink and {Van Der Vijgh}, {W. J F} and {Van Der Poort}, {S. E J M} and Henzen-Logmans, {S. C.} and Pinedo, {H. M.}",

year = "1984",

doi = "10.1016/S0304-3835(84)80027-0",

language = "English (US)",

volume = "25",

pages = "61--69",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats

AU - Elferink, F.

AU - Van Der Vijgh, W. J F

AU - Van Der Poort, S. E J M

AU - Henzen-Logmans, S. C.

AU - Pinedo, H. M.

PY - 1984

Y1 - 1984

N2 - Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.

AB - Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.

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