Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats

F. Elferink; W. J F Van Der Vijgh; S. E J M Van Der Poort; S. C. Henzen-Logmans; H. M. Pinedo

doi:10.1016/S0304-3835(84)80027-0

Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats

F. Elferink, W. J F Van Der Vijgh, S. E J M Van Der Poort, S. C. Henzen-Logmans, H. M. Pinedo

Research output: Contribution to journal › Article

Abstract

Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.

Original language	English (US)
Pages (from-to)	61-69
Number of pages	9
Journal	Cancer Letters
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(84)80027-0
Publication status	Published - 1984
Externally published	Yes

Fingerprint

ASJC Scopus subject areas

Cancer Research
Oncology
Molecular Biology

Cite this

Elferink, F., Van Der Vijgh, W. J. F., Van Der Poort, S. E. J. M., Henzen-Logmans, S. C., & Pinedo, H. M. (1984). Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats. Cancer Letters, 25(1), 61-69. https://doi.org/10.1016/S0304-3835(84)80027-0

@article{8bcb524e0c9b4391aa28136b548cb16b,

title = "Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats",

abstract = "Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5{\%} glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.",

author = "F. Elferink and {Van Der Vijgh}, {W. J F} and {Van Der Poort}, {S. E J M} and Henzen-Logmans, {S. C.} and Pinedo, {H. M.}",

year = "1984",

doi = "10.1016/S0304-3835(84)80027-0",

language = "English (US)",

volume = "25",

pages = "61--69",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats

AU - Elferink, F.

AU - Van Der Vijgh, W. J F

AU - Van Der Poort, S. E J M

AU - Henzen-Logmans, S. C.

AU - Pinedo, H. M.

PY - 1984

Y1 - 1984

N2 - Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.

AB - Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.

UR - http://www.scopus.com/inward/record.url?scp=0021738642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021738642&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(84)80027-0

DO - 10.1016/S0304-3835(84)80027-0

M3 - Article

C2 - 6542826

AN - SCOPUS:0021738642

VL - 25

SP - 61

EP - 69

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -

Access to Document

10.1016/S0304-3835(84)80027-0