Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats

F. Elferink, W. J F Van Der Vijgh, S. E J M Van Der Poort, S. C. Henzen-Logmans, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalCancer Letters
Volume25
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Biology

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