Abstract
Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 61-69 |
| Number of pages | 9 |
| Journal | Cancer Letters |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
- Molecular Biology
Cite this
Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats. / Elferink, F.; Van Der Vijgh, W. J F; Van Der Poort, S. E J M; Henzen-Logmans, S. C.; Pinedo, H. M.
In: Cancer Letters, Vol. 25, No. 1, 1984, p. 61-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats
AU - Elferink, F.
AU - Van Der Vijgh, W. J F
AU - Van Der Poort, S. E J M
AU - Henzen-Logmans, S. C.
AU - Pinedo, H. M.
PY - 1984
Y1 - 1984
N2 - Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.
AB - Aqueous solutions of the cisplatin analog aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) (TNO-6, spiroplatin) principally contain hydrolyzed and oligomerized molecules. Sodium sulfate reduces the hydrolysis of the sulfato ligand. We investigated the influence of the equilibrium state on nephrotoxicity of spiroplatin in rats receiving 3 doses of 3 mg/kg with an interval of 8 days. Rats (n = 6) treated with spiroplatin solubilized in isoosmotic sodium sulfate (impaired hydrolysis) showed less toxicity as measured by proteinuria, platinum excretion and body weight, than the group treated with spiroplatin solubilized in 5% glucose. This result indicates that the presence of hydrolysis products plays a role in the toxicity of spiroplatin.
UR - http://www.scopus.com/inward/record.url?scp=0021738642&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021738642&partnerID=8YFLogxK
U2 - 10.1016/S0304-3835(84)80027-0
DO - 10.1016/S0304-3835(84)80027-0
M3 - Article
C2 - 6542826
AN - SCOPUS:0021738642
VL - 25
SP - 61
EP - 69
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -