Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas

A. L. Oronsky; M. R. Nocenti

doi:10.3181/00379727-125-32340

Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas

A. L. Oronsky, M. R. Nocenti

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C¹⁴-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.

Original language	English (US)
Pages (from-to)	1297-1301
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	125
Issue number	4
DOIs	https://doi.org/10.3181/00379727-125-32340
State	Published - Sep 8 1967
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas",

abstract = "Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.",

author = "Oronsky, {A. L.} and Nocenti, {M. R.}",

note = "Funding Information: Supported in part by USPHS Training Grant 5T01-GM-00257 and Merck, Sharp and Dohme Research Gift. 8-9 1967 125 4 1297 1301 Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",

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AU - Oronsky, A. L.

AU - Nocenti, M. R.

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N2 - Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.

AB - Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.

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Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas

Abstract

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