Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas

A. L. Oronsky, M. R. Nocenti

Research output: Contribution to journalArticle

Abstract

Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.

Original languageEnglish (US)
Pages (from-to)1297-1301
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume125
Issue number4
DOIs
StatePublished - Sep 8 1967

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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