Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Sep 8 1967|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)