Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa

Louis Marie Yindom, Aleksandra Leligdowicz, Maureen P. Martin, Xiaojiang Gao, Ying Qi, Syed M.A. Zaman, Maarten Schim Van Der Loeff, Carla Van Tienen, Assan Jaye, Akum Aveika, Archibald Worwui, Mathurin Diatta, Tim Vincent, Hilton C. Whittle, Sarah L. Rowland-Jones, Robert Walton, Mary Carrington

Research output: Contribution to journalArticle

Abstract

Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B* 1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course.

Original languageEnglish (US)
Pages (from-to)8202-8208
Number of pages7
JournalJournal of virology
Volume84
Issue number16
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Fingerprint Dive into the research topics of 'Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa'. Together they form a unique fingerprint.

  • Cite this

    Yindom, L. M., Leligdowicz, A., Martin, M. P., Gao, X., Qi, Y., Zaman, S. M. A., Van Der Loeff, M. S., Van Tienen, C., Jaye, A., Aveika, A., Worwui, A., Diatta, M., Vincent, T., Whittle, H. C., Rowland-Jones, S. L., Walton, R., & Carrington, M. (2010). Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. Journal of virology, 84(16), 8202-8208. https://doi.org/10.1128/JVI.00116-10