Influence of factor 5 rs6025 and factor 2 rs1799963 mutation on inhibitor development in patients with hemophilia A - An Israeli-German multicenter database study

Gili Kenet, Christoph Bidlingmaier, Nadja Bogdanova, Carmen Escuriola Ettingshausen, Neil Goldenberg, Sven Gutsche, Susan Halimeh, Susanne Holzhauer, Karin Kurnik, Verena Limperger, Ralf Junker, Ulrike Nowak-Göttl

Research output: Contribution to journalArticlepeer-review

Abstract

Objective The present cohort study was performed to investigate the impact of the factor 5 rs6025 [F5] and the factor 2 rs1799963 [F2] mutations on high-titer inhibitor development [HRI] in patients with severe/moderate-severe hemophilia A [HA]. Patients and Methods 216 patients with F8 < 2% born between 1980 and 2011 were followed after initial HA diagnosis over the first 200 exposure days. The first HA patient per family who presented for diagnosis was included in the present study. Results 32 of 216 children [14.8%] tested for F5/F2 carried either the F5 or the F2 variant. HRI occurred in 14 out of 32 F5/F2-carriers compared with 40 of 184 without F5/F2. Multivariate analysis adjusted for F8 genotype, treatment intensity, first-line use of plasma derived FVIII versus recombinant FVIII concentrates revealed that the presence of F5/F2 independently increases the risk of HRI development to odds [OR] of 3.4. Large deletions in the F8 gene [OR: 5.10], patients from Israel [OR: 4.0], the increase of FVIII per one IU/kgbw [OR: 1.05] and birth year [OR: 1.12] were significantly associated with the risk to develop HRI. Conclusion Data presented here suggest that HRI development is of multifactorial origin and that F5 and F2 mutations may contribute to this risk.

Original languageEnglish (US)
Pages (from-to)544-549
Number of pages6
JournalThrombosis research
Volume133
Issue number4
DOIs
StatePublished - Apr 2014

Keywords

  • F2 rs1799963 mutation
  • F5 rs6025
  • Hemophilia A
  • High-titer inhibitor development

ASJC Scopus subject areas

  • Hematology

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