Influence of donor and recipient age in lung transplantation

Don Hayes, Sylvester M. Black, Joseph D. Tobias, Robert Higgins, Bryan A. Whitson

Research output: Contribution to journalArticle

Abstract

Background No restrictions exist for allocating donor lungs according to age in the United States.

Methods A retrospective cohort study was performed of lung transplant recipients from 1987 to 2013 through a query of the United Network for Organ Sharing (UNOS) thoracic database. Age thresholds used were recipients (R) aged 60 years (R60 group) and 65 years (R65 group) and donors aged 50 years; each sub-group was analyzed, totaling 8 groups.

Results Of 23,905 lung transplants, 23,704 were used for Kaplan-Meier analysis, 8,851 for multivariate Cox, and 3,206 for the R60 group and 3,212 for the R65 group propensity score-matching analysis. Kaplan-Meier analysis with log-rank test statistic indicated significant differences across binary measure of donor age with a threshold of 60 years (log-rank test: chi-square1 = 12.9558, p = 0.0003) and 65 years (log-rank test: chi-square1 = 15.5053, p = 0.0001). Multivariate Cox models demonstrated that donors aged

Conclusions Older donor lungs did not negatively affect survival in older recipients but limited outcomes in younger recipients.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalJournal of Heart and Lung Transplantation
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Lung Transplantation
Tissue Donors
Lung
Kaplan-Meier Estimate
Propensity Score
Proportional Hazards Models
Cohort Studies
Thorax
Retrospective Studies
Databases
Transplants
Survival

Keywords

  • age donor
  • lung transplantation
  • mismatch
  • recipient
  • survival

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery
  • Medicine(all)

Cite this

Influence of donor and recipient age in lung transplantation. / Hayes, Don; Black, Sylvester M.; Tobias, Joseph D.; Higgins, Robert; Whitson, Bryan A.

In: Journal of Heart and Lung Transplantation, Vol. 34, No. 1, 01.01.2015, p. 43-49.

Research output: Contribution to journalArticle

Hayes, Don ; Black, Sylvester M. ; Tobias, Joseph D. ; Higgins, Robert ; Whitson, Bryan A. / Influence of donor and recipient age in lung transplantation. In: Journal of Heart and Lung Transplantation. 2015 ; Vol. 34, No. 1. pp. 43-49.
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