Influence of Diabetes Mellitus Type 2 and Prolonged Estrogen Exposure on Risk of Breast Cancer Among Women in Armenia

Lilit Khachatryan, Robert Scharpf, Sarah Kagan

Research output: Contribution to journalArticlepeer-review

Abstract

Diabetesmellitus type 2 (DM2) and breast cancer (BrCa) are prevalent in Armenia. We investigated DM2, reproductive factors, and BrCa in a case control study of 302 women. Multiple logistic regression analyses revealed DM2 increased adjusted odds of BrCa by 5.53 (95% CI 1.34-22.81). Any birth was protective (adjusted OR = 0.36, 95% CI 0.20-0.66). Each year delay in first pregnancy increased risk (adjusted OR = 1.13, 95% CI 1.01-1.27) as did induced abortions (adjusted OR = 2.86, 95% CI 1.02-8.04). Odds ratios were adjusted for age and body mass index (BMI), which confounded associations between DM2 and BrCa. We suggest our findings imply the need for further investigation in Armenian and in other populations with similar characteristics.

Original languageEnglish (US)
Pages (from-to)953-971
Number of pages19
JournalHealth care for women international
Volume32
Issue number11
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Health Professions(all)

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