Influence of DHEA administration on 24-hour cortisol concentrations

Patricia D. Kroboth, Janet A. Amico, Roslyn A. Stone, Maggie Folan, Reginald F. Frye, Frank J. Kroboth, Kristin Bigos, Tanya J. Fabian, Ana M. Linares, Bruce G. Pollock, Charles Hakala

Research output: Contribution to journalArticle

Abstract

DHEA is marketed and readily available as a daily nutritional supplement to counteract the effects of aging. The effect of DHEA administration on 24-hour plasma cortisol profiles has not been investigated. In this single-blind placebo-controlled crossover study, the effect of DHEA administration on cortisol concentrations was evaluated in healthy older women and men. Once each morning, subjects took either placebo (Days 1 to 7, and 23 to 29) or oral DHEA 200 mg (Days 8 to 22: doses 1 to 15). Twenty-four hour DHEA and cortisol concentrations were measured on Day 1 (placebo), Day 8 (DHEA dose 1), Day 15 (DHEA dose 8), Day 22 (DHEA dose 15), and Day 29 (placebo washout dose 7). DHEA administration resulted in a decrease in plasma cortisol concentrations (mean, peak, and/or AUC) in healthy older women and men. The cortisol-lowering effect of DHEA was more pronounced in women than in men in our study; pairwise differences in concentrations between days showed that relative to Day 1, cortisol was lower on Days 15, 22, and 29 in women (p = 0.0001) and on Day 15 in men (p = 0.002). The mechanism by which DHEA lowers plasma cortisol concentrations merits further investigation.

Original languageEnglish (US)
Pages (from-to)96-99
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume23
Issue number1
DOIs
StatePublished - Feb 2003
Externally publishedYes

Fingerprint

Dehydroepiandrosterone
Hydrocortisone
Placebos
Cross-Over Studies
Area Under Curve

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kroboth, P. D., Amico, J. A., Stone, R. A., Folan, M., Frye, R. F., Kroboth, F. J., ... Hakala, C. (2003). Influence of DHEA administration on 24-hour cortisol concentrations. Journal of Clinical Psychopharmacology, 23(1), 96-99. https://doi.org/10.1097/00004714-200302000-00014

Influence of DHEA administration on 24-hour cortisol concentrations. / Kroboth, Patricia D.; Amico, Janet A.; Stone, Roslyn A.; Folan, Maggie; Frye, Reginald F.; Kroboth, Frank J.; Bigos, Kristin; Fabian, Tanya J.; Linares, Ana M.; Pollock, Bruce G.; Hakala, Charles.

In: Journal of Clinical Psychopharmacology, Vol. 23, No. 1, 02.2003, p. 96-99.

Research output: Contribution to journalArticle

Kroboth, PD, Amico, JA, Stone, RA, Folan, M, Frye, RF, Kroboth, FJ, Bigos, K, Fabian, TJ, Linares, AM, Pollock, BG & Hakala, C 2003, 'Influence of DHEA administration on 24-hour cortisol concentrations', Journal of Clinical Psychopharmacology, vol. 23, no. 1, pp. 96-99. https://doi.org/10.1097/00004714-200302000-00014
Kroboth, Patricia D. ; Amico, Janet A. ; Stone, Roslyn A. ; Folan, Maggie ; Frye, Reginald F. ; Kroboth, Frank J. ; Bigos, Kristin ; Fabian, Tanya J. ; Linares, Ana M. ; Pollock, Bruce G. ; Hakala, Charles. / Influence of DHEA administration on 24-hour cortisol concentrations. In: Journal of Clinical Psychopharmacology. 2003 ; Vol. 23, No. 1. pp. 96-99.
@article{882955edad614973bba250fa9d4cd3ee,
title = "Influence of DHEA administration on 24-hour cortisol concentrations",
abstract = "DHEA is marketed and readily available as a daily nutritional supplement to counteract the effects of aging. The effect of DHEA administration on 24-hour plasma cortisol profiles has not been investigated. In this single-blind placebo-controlled crossover study, the effect of DHEA administration on cortisol concentrations was evaluated in healthy older women and men. Once each morning, subjects took either placebo (Days 1 to 7, and 23 to 29) or oral DHEA 200 mg (Days 8 to 22: doses 1 to 15). Twenty-four hour DHEA and cortisol concentrations were measured on Day 1 (placebo), Day 8 (DHEA dose 1), Day 15 (DHEA dose 8), Day 22 (DHEA dose 15), and Day 29 (placebo washout dose 7). DHEA administration resulted in a decrease in plasma cortisol concentrations (mean, peak, and/or AUC) in healthy older women and men. The cortisol-lowering effect of DHEA was more pronounced in women than in men in our study; pairwise differences in concentrations between days showed that relative to Day 1, cortisol was lower on Days 15, 22, and 29 in women (p = 0.0001) and on Day 15 in men (p = 0.002). The mechanism by which DHEA lowers plasma cortisol concentrations merits further investigation.",
author = "Kroboth, {Patricia D.} and Amico, {Janet A.} and Stone, {Roslyn A.} and Maggie Folan and Frye, {Reginald F.} and Kroboth, {Frank J.} and Kristin Bigos and Fabian, {Tanya J.} and Linares, {Ana M.} and Pollock, {Bruce G.} and Charles Hakala",
year = "2003",
month = "2",
doi = "10.1097/00004714-200302000-00014",
language = "English (US)",
volume = "23",
pages = "96--99",
journal = "Journal of Clinical Psychopharmacology",
issn = "0271-0749",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Influence of DHEA administration on 24-hour cortisol concentrations

AU - Kroboth, Patricia D.

AU - Amico, Janet A.

AU - Stone, Roslyn A.

AU - Folan, Maggie

AU - Frye, Reginald F.

AU - Kroboth, Frank J.

AU - Bigos, Kristin

AU - Fabian, Tanya J.

AU - Linares, Ana M.

AU - Pollock, Bruce G.

AU - Hakala, Charles

PY - 2003/2

Y1 - 2003/2

N2 - DHEA is marketed and readily available as a daily nutritional supplement to counteract the effects of aging. The effect of DHEA administration on 24-hour plasma cortisol profiles has not been investigated. In this single-blind placebo-controlled crossover study, the effect of DHEA administration on cortisol concentrations was evaluated in healthy older women and men. Once each morning, subjects took either placebo (Days 1 to 7, and 23 to 29) or oral DHEA 200 mg (Days 8 to 22: doses 1 to 15). Twenty-four hour DHEA and cortisol concentrations were measured on Day 1 (placebo), Day 8 (DHEA dose 1), Day 15 (DHEA dose 8), Day 22 (DHEA dose 15), and Day 29 (placebo washout dose 7). DHEA administration resulted in a decrease in plasma cortisol concentrations (mean, peak, and/or AUC) in healthy older women and men. The cortisol-lowering effect of DHEA was more pronounced in women than in men in our study; pairwise differences in concentrations between days showed that relative to Day 1, cortisol was lower on Days 15, 22, and 29 in women (p = 0.0001) and on Day 15 in men (p = 0.002). The mechanism by which DHEA lowers plasma cortisol concentrations merits further investigation.

AB - DHEA is marketed and readily available as a daily nutritional supplement to counteract the effects of aging. The effect of DHEA administration on 24-hour plasma cortisol profiles has not been investigated. In this single-blind placebo-controlled crossover study, the effect of DHEA administration on cortisol concentrations was evaluated in healthy older women and men. Once each morning, subjects took either placebo (Days 1 to 7, and 23 to 29) or oral DHEA 200 mg (Days 8 to 22: doses 1 to 15). Twenty-four hour DHEA and cortisol concentrations were measured on Day 1 (placebo), Day 8 (DHEA dose 1), Day 15 (DHEA dose 8), Day 22 (DHEA dose 15), and Day 29 (placebo washout dose 7). DHEA administration resulted in a decrease in plasma cortisol concentrations (mean, peak, and/or AUC) in healthy older women and men. The cortisol-lowering effect of DHEA was more pronounced in women than in men in our study; pairwise differences in concentrations between days showed that relative to Day 1, cortisol was lower on Days 15, 22, and 29 in women (p = 0.0001) and on Day 15 in men (p = 0.002). The mechanism by which DHEA lowers plasma cortisol concentrations merits further investigation.

UR - http://www.scopus.com/inward/record.url?scp=12244307847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12244307847&partnerID=8YFLogxK

U2 - 10.1097/00004714-200302000-00014

DO - 10.1097/00004714-200302000-00014

M3 - Article

C2 - 12544381

AN - SCOPUS:12244307847

VL - 23

SP - 96

EP - 99

JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

SN - 0271-0749

IS - 1

ER -