Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

R. A. Kaslow; M. Carrington; R. Apple; L. Park; A. Muñoz; A. J. Saah; J. J. Goedert; C. Winkler; S. J. O'Brien; C. Rinaldo; R. Detels; W. Blattner; J. Phair; H. Erlich; D. L. Mann

doi:10.1038/nm0496-405

Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

R. A. Kaslow, M. Carrington, R. Apple, L. Park, A. Muñoz, A. J. Saah, J. J. Goedert, C. Winkler, S. J. O'Brien, C. Rinaldo, R. Detels, W. Blattner, J. Phair, H. Erlich, D. L. Mann

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Abstract

Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human immunodeficiency virus type 1 (HIV-1). Comprehensive statistical analysis produced an HLA profile that predicted time from HIV-1 infection to the onset of AIDS. The profile was developed in a cohort of 139 men and evaluated in a second unrelated cohort of 102 men. In the evaluation cohort, the profile discriminated a sixfold difference between groups with the shortest and longest times to AIDS (P = 0.001). These findings support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.

Original language	English (US)
Pages (from-to)	405-411
Number of pages	7
Journal	Nature medicine
Volume	2
Issue number	4
DOIs	https://doi.org/10.1038/nm0496-405
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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Kaslow, R. A., Carrington, M., Apple, R., Park, L., Muñoz, A., Saah, A. J., Goedert, J. J., Winkler, C., O'Brien, S. J., Rinaldo, C., Detels, R., Blattner, W., Phair, J., Erlich, H., & Mann, D. L. (1996). Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nature medicine, 2(4), 405-411. https://doi.org/10.1038/nm0496-405

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title = "Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection",

abstract = "Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human immunodeficiency virus type 1 (HIV-1). Comprehensive statistical analysis produced an HLA profile that predicted time from HIV-1 infection to the onset of AIDS. The profile was developed in a cohort of 139 men and evaluated in a second unrelated cohort of 102 men. In the evaluation cohort, the profile discriminated a sixfold difference between groups with the shortest and longest times to AIDS (P = 0.001). These findings support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.",

author = "Kaslow, {R. A.} and M. Carrington and R. Apple and L. Park and A. Mu{\~n}oz and Saah, {A. J.} and Goedert, {J. J.} and C. Winkler and O'Brien, {S. J.} and C. Rinaldo and R. Detels and W. Blattner and J. Phair and H. Erlich and Mann, {D. L.}",

note = "Funding Information: From the University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA; the Department of Medicine, University of Maryland, Baltimore; and the Department of Kinesiology, University of Maryland, College Park, MD. Submitted April 7, 2001; accepted June 25, 2001. Supported by grants from the Andrus Foundation and the Pennsylvania Heart Association. G.E.M. was supported by NIH Grant No. K08 HL-03029. Address reprint requests to James M. Hagberg, PhD, Department of Kinesiology, University of Maryland, College Park, MD 20742. Copyright {\textcopyright} 2001 by W.B. Saunders Company 0026-0495/01/5012-0015$35.00/0 doi:10.1053/meta.2001.28140",

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AU - Muñoz, A.

AU - Saah, A. J.

AU - Goedert, J. J.

AU - Winkler, C.

AU - O'Brien, S. J.

AU - Rinaldo, C.

AU - Detels, R.

AU - Blattner, W.

AU - Phair, J.

AU - Erlich, H.

AU - Mann, D. L.

N1 - Funding Information: From the University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA; the Department of Medicine, University of Maryland, Baltimore; and the Department of Kinesiology, University of Maryland, College Park, MD. Submitted April 7, 2001; accepted June 25, 2001. Supported by grants from the Andrus Foundation and the Pennsylvania Heart Association. G.E.M. was supported by NIH Grant No. K08 HL-03029. Address reprint requests to James M. Hagberg, PhD, Department of Kinesiology, University of Maryland, College Park, MD 20742. Copyright © 2001 by W.B. Saunders Company 0026-0495/01/5012-0015$35.00/0 doi:10.1053/meta.2001.28140

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AB - Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human immunodeficiency virus type 1 (HIV-1). Comprehensive statistical analysis produced an HLA profile that predicted time from HIV-1 infection to the onset of AIDS. The profile was developed in a cohort of 139 men and evaluated in a second unrelated cohort of 102 men. In the evaluation cohort, the profile discriminated a sixfold difference between groups with the shortest and longest times to AIDS (P = 0.001). These findings support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.

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Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

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